KFU. Card publication. Synthesis and Antiglycation Activity of Pyridoxine Azo Derivatives

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SYNTHESIS AND ANTIGLYCATION ACTIVITY OF PYRIDOXINE AZO DERIVATIVES

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

Язык

русский

Authors, employees of KFU

Agafonova Mariya Nikolaevna, author

Badeev Yuriy Vladimirovich, author

Belova Margarita Alekseevna, author

Burilov Vladimir Aleksandrovich, author

Vasileva Olga Sergeevna, author

Grishaev Denis Yurevich, author

Ivanov Stanislav Aleksandrovich, author

Nikishova Tatyana Vladimirovna, author

Ocherednyuk Evgeniy Alekseevich, author

Strelnik Aleksey Dmitrievich, author

Fafanova Ekaterina Mikhaylovna, author

Shtyrlin Yuriy Grigorevich, author

Other authors

Gnezdilov Oleg Ivanovich, author

Bibliographic description in the original language

Strelnik A.D. Synthesis and Antiglycation Activity of Pyridoxine Azo Derivatives / A.D. Strelnik, M.A. Belova, O.S. Vasilieva, E.M. Fafanova, O.I. Gnezdilov , S.A. Ivanov, T.V. Nikishova, Y.V. Badeev, E.A. Ocherednyuk, V.A. Burilov, D.Y. Grishaev, M.N. Agafonova,Y.G. Shtyrlin // Russian Journal of General Chemistry. - 2024. - Vol. 94, No. 11. - P. 2868–2882.

Annotation

An approach to the synthesis of pyridoxine azo derivatives based on aminophenols was developed. 52 new pyridoxine derivatives were synthesized. An in vitro study of antiglycation properties showed that most of the prepared pyridoxine azo derivatives (IC50 = 10–191 μM) significantly exceed the phase I-II clinical trials drugs aminoguanidine (IC50 = 526 μM) and pyridoxamine (IC50 = 834 μM) in their activity. Some of the obtained compounds also have high antioxidant activity and effectively inhibit lipid peroxidation.

Keywords

pyridoxine derivatives, azo compounds, advanced glycation end products, antiglycation activity

The name of the journal

Russian Journal of General Chemistry

URL

https://rdcu.be/d4LuN

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=308729&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Agafonova Mariya Nikolaevna	ru_RU
dc.contributor.author	Badeev Yuriy Vladimirovich	ru_RU
dc.contributor.author	Belova Margarita Alekseevna	ru_RU
dc.contributor.author	Burilov Vladimir Aleksandrovich	ru_RU
dc.contributor.author	Vasileva Olga Sergeevna	ru_RU
dc.contributor.author	Grishaev Denis Yurevich	ru_RU
dc.contributor.author	Ivanov Stanislav Aleksandrovich	ru_RU
dc.contributor.author	Nikishova Tatyana Vladimirovna	ru_RU
dc.contributor.author	Ocherednyuk Evgeniy Alekseevich	ru_RU
dc.contributor.author	Strelnik Aleksey Dmitrievich	ru_RU
dc.contributor.author	Fafanova Ekaterina Mikhaylovna	ru_RU
dc.contributor.author	Shtyrlin Yuriy Grigorevich	ru_RU
dc.contributor.author	Gnezdilov Oleg Ivanovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Strelnik A.D. Synthesis and Antiglycation Activity of Pyridoxine Azo Derivatives / A.D. Strelnik, M.A. Belova, O.S. Vasilieva, E.M. Fafanova, O.I. Gnezdilov , S.A. Ivanov, T.V. Nikishova, Y.V. Badeev, E.A. Ocherednyuk, V.A. Burilov, D.Y. Grishaev, M.N. Agafonova,Y.G. Shtyrlin // Russian Journal of General Chemistry. - 2024. - Vol. 94, No. 11. - P. 2868–2882.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=308729&p_lang=2	ru_RU
dc.description.abstract	Russian Journal of General Chemistry	ru_RU
dc.description.abstract	An approach to the synthesis of pyridoxine azo derivatives based on aminophenols was developed. 52 new pyridoxine derivatives were synthesized. An in vitro study of antiglycation properties showed that most of the prepared pyridoxine azo derivatives (IC50 = 10–191 μM) significantly exceed the phase I-II clinical trials drugs aminoguanidine (IC50 = 526 μM) and pyridoxamine (IC50 = 834 μM) in their activity. Some of the obtained compounds also have high antioxidant activity and effectively inhibit lipid peroxidation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	pyridoxine derivatives	ru_RU
dc.subject	azo compounds	ru_RU
dc.subject	advanced glycation end products	ru_RU
dc.subject	antiglycation activity	ru_RU
dc.title	Synthesis and Antiglycation Activity of Pyridoxine Azo Derivatives	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU