KFU. Card publication. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments

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FEDERAL UNIVERSITY

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SYNTHESIS AND SELECTIVE CU(II) COMPLEXATION OF LOWER RIM SUBSTITUTED THIACALIXARENES CONTAINING PYRAZOLE FRAGMENTS

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

Язык

английский

Authors, employees of KFU

Bukharov Mikhail Sergeevich, author

Islamov Daut Rinatovich, author

Kalinin Valeriy Igorevich, author

Stoykov Ivan Ivanovich, author

Shibaeva Kseniya Sergeevna, author

Other authors

Babaeva Olga , author

Authors, students KFU

Rasperetikhina Ekaterina Valerevna, author

Bibliographic description in the original language

Kalinin V. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments / V. Kalinin, E. Rasperetikhina, M. Bukharov, K. Shibaeva, D. Islamov, O. Babaeva, I. Stoikov // Chimica Techno Acta. - 2024. - V.11(4). - 202411418.

Annotation

Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions in Wilsons and Menkes diseases at the cellular level. Such sensors must have a high specificity for this cation as well as low toxicity. A synthetic approach for the preparation of selective sensors for Cu(II) cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties in cone, partial cone and 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR and IR spectroscopy, MALDI MS, and elemental analysis. All synthesized thiacalixarene compounds formed complexes with Cu(II) with the binding constants in range logK = 4.44–4.63 and 1:1 stoichiometry. The structure of the obtained complexes was studied by NMR spectroscopy and DFT methods. The obtained results can be used to develop selective Cu(II) sensors.

Keywords

hiacalixarenes, pyrazoles, synthesis, copper(II) cation, sensors, selectivity.

The name of the journal

Chimica Techno Acta

URL

https://chimicatechnoacta.ru/article/view/8262

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=307058&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bukharov Mikhail Sergeevich	ru_RU
dc.contributor.author	Islamov Daut Rinatovich	ru_RU
dc.contributor.author	Kalinin Valeriy Igorevich	ru_RU
dc.contributor.author	Stoykov Ivan Ivanovich	ru_RU
dc.contributor.author	Shibaeva Kseniya Sergeevna	ru_RU
dc.contributor.author	Babaeva Olga	ru_RU
dc.contributor.author	Rasperetikhina Ekaterina Valerevna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Kalinin V. Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments / V. Kalinin, E. Rasperetikhina, M. Bukharov, K. Shibaeva, D. Islamov, O. Babaeva, I. Stoikov // Chimica Techno Acta. - 2024. - V.11(4). - 202411418.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=307058&p_lang=2	ru_RU
dc.description.abstract	Chimica Techno Acta	ru_RU
dc.description.abstract	Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions in Wilsons and Menkes diseases at the cellular level. Such sensors must have a high specificity for this cation as well as low toxicity. A synthetic approach for the preparation of selective sensors for Cu(II) cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties in cone, partial cone and 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR and IR spectroscopy, MALDI MS, and elemental analysis. All synthesized thiacalixarene compounds formed complexes with Cu(II) with the binding constants in range logK = 4.44–4.63 and 1:1 stoichiometry. The structure of the obtained complexes was studied by NMR spectroscopy and DFT methods. The obtained results can be used to develop selective Cu(II) sensors.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hiacalixarenes	ru_RU
dc.subject	pyrazoles	ru_RU
dc.subject	synthesis	ru_RU
dc.subject	copper(II) cation	ru_RU
dc.subject	sensors	ru_RU
dc.subject	selectivity.	ru_RU
dc.title	Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU