KFU. Card publication. Terpenes-modified lipid nanosystems for temozolomide, improving cytotoxicity against glioblastoma human cancer cells in vitro

- RUS
- 中文
- ES

TERPENES-MODIFIED LIPID NANOSYSTEMS FOR TEMOZOLOMIDE, IMPROVING CYTOTOXICITY AGAINST GLIOBLASTOMA HUMAN CANCER CELLS IN VITRO

Form of presentation

Articles in international journals and collections

Year of publication

2024

��

��

Authors, employees of KFU

Mironov Vladimir Fedorovich, author

Bibliographic description in the original language

T.N.Pashirova, A.V.Nemtarev, D.Buzyurova, Z.Shajhutdinova, M.N.Dimukhametov, V.M.Babaev, A.D.Voloshina, V.F.Mironov. Terpenes-modified lipid nanosystems for temozolomide, improving cytotoxicity against glioblastoma human cancer cells in vitro. // Nanomaterials, 2024. Vol. 14. Art. No. 55. Doi 10.3390/nano14010055.

Annotation

Currently, increasing the efficiency of glioblastoma treatment is still an unsolved problem. In this study, a combination of promising approaches was proposed: (i) an application of nanotechnology approach to create a new terpene-modified lipid system (7% w/w), using soybean L-α-phosphatidylcholine, N-carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine for delivery of the chemotherapy drug, temozolomide (TMZ, 1 mg/mL); (ii) use of TMZ associated with natural compounds—terpenes (1% w/w) abietic acid and Abies sibirica Ledeb. resin (A. sibirica). Different concentrations and combinations of terpene–lipid systems were employed to treat human cancer cell lines T 98G (glioblastoma), M-Hela (carcinoma of the cervix) and human liver cell lines (Chang liver). The terpene–lipid systems appeared to be unilamellar and of spherical shape under transmission electron microscopy (TEM). The creation of a TMZ-loaded terpene–lipid nanosystem was about 100 nm in diameter with a negative surface charge found by dynamic light scattering. The 74% encapsulation efficiency allowed the release time of TMZ to be prolonged. The modification by terpenes of TMZ-loaded lipid nanoparticles improved by four times the cytotoxicity against human cancer T 98G cells and decreased the cytotoxicity against human normal liver cells. Terpene-modified delivery lipid systems are of potential interest as a combination therapy.

Keywords

lipid nanoparticles, terpenes, temozolomide, abietic acid, Abies sibirica Ledeb. resin

The name of the journal

Nanomaterials

URL

https://doi.org/10.3390/nano14010055

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=306757&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Mironov Vladimir Fedorovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	T.N.Pashirova, A.V.Nemtarev, D.Buzyurova, Z.Shajhutdinova, M.N.Dimukhametov, V.M.Babaev, A.D.Voloshina, V.F.Mironov. Terpenes-modified lipid nanosystems for temozolomide, improving cytotoxicity against glioblastoma human cancer cells in vitro. // Nanomaterials, 2024. Vol. 14. Art. No. 55. Doi 10.3390/nano14010055.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=306757&p_lang=2	ru_RU
dc.description.abstract	Nanomaterials	ru_RU
dc.description.abstract	Currently, increasing the efficiency of glioblastoma treatment is still an unsolved problem. In this study, a combination of promising approaches was proposed: (i) an application of nanotechnology approach to create a new terpene-modified lipid system (7% w/w), using soybean L-α-phosphatidylcholine, N-carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine for delivery of the chemotherapy drug, temozolomide (TMZ, 1 mg/mL); (ii) use of TMZ associated with natural compounds—terpenes (1% w/w) abietic acid and Abies sibirica Ledeb. resin (A. sibirica). Different concentrations and combinations of terpene–lipid systems were employed to treat human cancer cell lines T 98G (glioblastoma), M-Hela (carcinoma of the cervix) and human liver cell lines (Chang liver). The terpene–lipid systems appeared to be unilamellar and of spherical shape under transmission electron microscopy (TEM). The creation of a TMZ-loaded terpene–lipid nanosystem was about 100 nm in diameter with a negative surface charge found by dynamic light scattering. The 74% encapsulation efficiency allowed the release time of TMZ to be prolonged. The modification by terpenes of TMZ-loaded lipid nanoparticles improved by four times the cytotoxicity against human cancer T 98G cells and decreased the cytotoxicity against human normal liver cells. Terpene-modified delivery lipid systems are of potential interest as a combination therapy.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	lipid nanoparticles	ru_RU
dc.subject	terpenes	ru_RU
dc.subject	temozolomide	ru_RU
dc.subject	abietic acid	ru_RU
dc.subject	Abies sibirica Ledeb. resin	ru_RU
dc.title	Terpenes-modified lipid nanosystems for temozolomide, improving cytotoxicity against glioblastoma human cancer cells in vitro	ru_RU
dc.type	Articles in international journals and collections	ru_RU