KFU. Card publication. Structural mechanisms of protection of parasitic larvae from the host's immune factors in the Triaenophorus nodulosus (Cestoda)

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STRUCTURAL MECHANISMS OF PROTECTION OF PARASITIC LARVAE FROM THE HOST'S IMMUNE FACTORS IN THE TRIAENOPHORUS NODULOSUS (CESTODA) &NDASH; PERCH SYSTEM

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

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Authors, employees of KFU

Biserova Natalya Mikhaylovna, author

Bibliographic description in the original language

Kolesnikov I.A., Biserova N.M. 2024. Structural mechanisms of protection of parasitic larvae from the host's immune factors in the Triaenophorus nodulosus (Cestoda) – perch system. Moscow University Biological Sciences Bulletin, 2024, Vol. 79, No. 2, pp. 70–77. ? Allerton Press, Inc., 2024. ISSN 0096-3925. DOI: 10.3103/S009639252460087X

Annotation

Abstract—A structural aspect of the parasite–host interactions in the Triaenophorus nodulosus– European perch system was studied; a number of structural mechanisms involved in the parasite's protective reaction against the host's immune response were identified. Plerocercoids are localized in the liver of the intermediate fish host. In response to invasion, a parasitic granuloma is formed from the host tissues forming a closed capsule around the parasite. It was demonstrated that the capsule wall is multilayered and consists of several cell types. The outer layer (fibrous) is represented by fibroblasts and connective tissue fibers. The inner layer is formed by several rows of flattened epithelioid cells tightly adjacent to each other and connected by desmosomes. Individual macrophages exhibiting a phagocytic activity were found on the inner surface of the capsule wall. Structural diversity of the cellular elements of the granuloma wall depends on time elapsed since infection and physiological state of the host. Phagocytosis of apical parts of microtriches and tumuli by granuloma macrophages was described for the first time. Crystal-like structures of unknown origin were also found for the first time in the capsule cavity. The plerocercoid is located freely in the capsule cavity and has formed hooks that (unlike the intestinal stage) are covered with the tegument cytoplasm. The tegument secretes a thick layer of filamentous matrix, extracellular vesicles, and vacuolized microtriches onto the surface. Terminals of specialized cells secrete three types of secretory products: secretion of frontal glands, secretion of tumuli, and neurosecretion of cup-shaped terminals. Universal structural adaptations common to all stages of parasite development and specialized ones common to tissue plerocercoids were detected. Vacuolized microtriches belong to the specialized structures that arise in response to the host immunity.

Keywords

Bothriocephalidea, glands, secretory?excretory products, tegument, parasitic capsule, parasite?host interface

The name of the journal

Moscow University Biological Sciences Bulletin

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=306047&p_lang=2

Resource files

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2024_Kolesnikov_Biserova_ENG_BBSM70.pdf	2,28	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Biserova Natalya Mikhaylovna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Kolesnikov I.A., Biserova N.M. 2024. Structural mechanisms of protection of parasitic larvae from the host's immune factors in the Triaenophorus nodulosus (Cestoda) – perch system. Moscow University Biological Sciences Bulletin, 2024, Vol. 79, No. 2, pp. 70–77. ? Allerton Press, Inc., 2024. ISSN 0096-3925. DOI: 10.3103/S009639252460087X	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=306047&p_lang=2	ru_RU
dc.description.abstract	Moscow University Biological Sciences Bulletin	ru_RU
dc.description.abstract	Abstract—A structural aspect of the parasite–host interactions in the Triaenophorus nodulosus– European perch system was studied; a number of structural mechanisms involved in the parasite's protective reaction against the host's immune response were identified. Plerocercoids are localized in the liver of the intermediate fish host. In response to invasion, a parasitic granuloma is formed from the host tissues forming a closed capsule around the parasite. It was demonstrated that the capsule wall is multilayered and consists of several cell types. The outer layer (fibrous) is represented by fibroblasts and connective tissue fibers. The inner layer is formed by several rows of flattened epithelioid cells tightly adjacent to each other and connected by desmosomes. Individual macrophages exhibiting a phagocytic activity were found on the inner surface of the capsule wall. Structural diversity of the cellular elements of the granuloma wall depends on time elapsed since infection and physiological state of the host. Phagocytosis of apical parts of microtriches and tumuli by granuloma macrophages was described for the first time. Crystal-like structures of unknown origin were also found for the first time in the capsule cavity. The plerocercoid is located freely in the capsule cavity and has formed hooks that (unlike the intestinal stage) are covered with the tegument cytoplasm. The tegument secretes a thick layer of filamentous matrix, extracellular vesicles, and vacuolized microtriches onto the surface. Terminals of specialized cells secrete three types of secretory products: secretion of frontal glands, secretion of tumuli, and neurosecretion of cup-shaped terminals. Universal structural adaptations common to all stages of parasite development and specialized ones common to tissue plerocercoids were detected. Vacuolized microtriches belong to the specialized structures that arise in response to the host immunity.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bothriocephalidea	ru_RU
dc.subject	glands	ru_RU
dc.subject	secretory?excretory products	ru_RU
dc.subject	tegument	ru_RU
dc.subject	parasitic capsule	ru_RU
dc.subject	parasite?host interface	ru_RU
dc.title	Structural mechanisms of protection of parasitic larvae from the host's immune factors in the Triaenophorus nodulosus (Cestoda) – perch system	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU