KFU. Card publication. EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT

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FEDERAL UNIVERSITY

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EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT

Form of presentation

Articles in Russian journals and collections

Year of publication

2024

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Authors, employees of KFU

Ryzhkin Sergey Aleksandrovich, author

Bibliographic description in the original language

EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT / T.R. Gaynutdinov, S.A. Ryzhkin, R.F. Shavaliev, K.N. Vagin, Y.A. Kurbangaleev, F.H. Kalimullin, E.M. Plotnikova, A.M. Idrisov, S.E. Ohrimenko, E.N. Mayorova // Extreme Medicine. - 2024. - � 2. - p. 63-71.

Annotation

The study is relevant due to the fact that the decrease in microbial toxicity observed during the radio-inactivation of microorganisms is accompanied by synthesis of radioprotective substances and exertion of the radioprotective effects associated with administration of such microbial agents to exposed animals. The study was aimed to assess radioprotective efficacy of the exposed Staphylococcus aureus variants. The study showed that the Staphylococcus aureus culture treated with a single dose of gamma radiation (30–40 kGy) ensured protection of 55–66% of the lethally irradiated animals. Multiple exposures of the test microorganism to the gradually increasing doses of gamma radiation induced an even larger increase in radioresistance resulting from the synthesis of endogenic radioprotectors, particularly peroxidase, the antioxidant enzyme, and IL1β cytokine, ensuring interception of the radiation-induced toxic radicals and thereby preventing postexposure pancytopenia in the bone marrow. The experiments involving white mice exposed to the absolutely lethal gamma radiation doses (7.9 Gy, LD100/30) showed that a single subcutaneous administration of the St. aureus radioresistant variant (strain 209R70) in a dose of 2 × 108 bacterial cells per animal 3 days after the exposure ensured the 77.7% survival rate, while 100% of untreated animals died. Based on the findings it was concluded that inclusion of the exposed agents of microbial origin would make it possible to increase the efficacy of the combination radioprotectors.

Keywords

Staphylococcus aureus, gamma rays, radio inactivation, radio modification, laboratory animals, anti-radiation effectiveness

The name of the journal

Extreme Medicine (MEDICINE OF EXTREME SITUATIONS)

URL

https://mes.fmba.press/archive/2024/2/7/abstract?lang=en

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=304069&p_lang=2

Resource files

File name	Size (MB)	Format
2024_2_1478_en.pdf	0,97	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ryzhkin Sergey Aleksandrovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT / T.R. Gaynutdinov, S.A. Ryzhkin, R.F. Shavaliev, K.N. Vagin, Y.A. Kurbangaleev, F.H. Kalimullin, E.M. Plotnikova, A.M. Idrisov, S.E. Ohrimenko, E.N. Mayorova // Extreme Medicine. - 2024. - � 2. - p. 63-71.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=304069&p_lang=2	ru_RU
dc.description.abstract	Extreme Medicine (MEDICINE OF EXTREME SITUATIONS)	ru_RU
dc.description.abstract	The study is relevant due to the fact that the decrease in microbial toxicity observed during the radio-inactivation of microorganisms is accompanied by synthesis of radioprotective substances and exertion of the radioprotective effects associated with administration of such microbial agents to exposed animals. The study was aimed to assess radioprotective efficacy of the exposed Staphylococcus aureus variants. The study showed that the Staphylococcus aureus culture treated with a single dose of gamma radiation (30–40 kGy) ensured protection of 55–66% of the lethally irradiated animals. Multiple exposures of the test microorganism to the gradually increasing doses of gamma radiation induced an even larger increase in radioresistance resulting from the synthesis of endogenic radioprotectors, particularly peroxidase, the antioxidant enzyme, and IL1β cytokine, ensuring interception of the radiation-induced toxic radicals and thereby preventing postexposure pancytopenia in the bone marrow. The experiments involving white mice exposed to the absolutely lethal gamma radiation doses (7.9 Gy, LD100/30) showed that a single subcutaneous administration of the St. aureus radioresistant variant (strain 209R70) in a dose of 2 × 108 bacterial cells per animal 3 days after the exposure ensured the 77.7% survival rate, while 100% of untreated animals died. Based on the findings it was concluded that inclusion of the exposed agents of microbial origin would make it possible to increase the efficacy of the combination radioprotectors.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Staphylococcus aureus	ru_RU
dc.subject	gamma rays	ru_RU
dc.subject	radio inactivation	ru_RU
dc.subject	radio modification	ru_RU
dc.subject	laboratory animals	ru_RU
dc.subject	anti-radiation effectiveness	ru_RU
dc.title	EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU