KFU. Card publication. Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

STUDY OF SELF-ORGANIZATION AND STRUCTURAL PHASE TRANSITIONS IN WATER /AOT / ISOPROPYL MYRISTATE BIOCOMPATIBLE SYSTEM

Form of presentation

Articles in international journals and collections

Year of publication

2024

��

��

Authors, employees of KFU

Gnezdilov Oleg Ivanovich, author

Bibliographic description in the original language

Sautina N.V. Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system/ N.V. Sautina, O.I. Gnezdilov, A.T. Gubaidullin, Yu.G. Galyametdinov// Journal of Molecular Liquids. -2024. – V.407. – 125193.

Annotation

This work reports preparation and characterization of biocompatible sodium bis(2-ethylhexyl) sulfosuccinate (AOT) / water/ isopropyl myristate (IPM) systems. We studied their ability to form various self-organized structures such as microemulsions and liquid crystal templates for producing nanoparticles such as drug delivery vehicles, which play an important role in delivery of various substances. We determined concentration and temperature conditions that allow for forming various structures in this system and characterized the structural phase transition from the microemulsion to liquid crystalline phase, which is important for delivery of bioactive compounds. The parameters of the liquid crystalline phase of the water/AOT/isopropyl myristate system were calculated for the first time in this work. The sizes of microemulsion droplets were determined. To describe molecular motions in the studied microemulsion, self-diffusion coefficients of each component were measured. The values of relative diffusion coefficients demonstrated that reverse microemulsions were observed at AOT concentrations up to 60 % wt. Further increase in surfactant concentration slows down their molecular mobility and results in formation of aggregates with a bimodal size distribution and a subsequent formation of the hexagonal liquid crystalline phase. Geometry of the mesophase and its structure were investigated by X-ray diffraction. The respective phase diagram was plotted and analyzed using the data of polarized light microscopy, dynamic light scattering, and NMR self-diffusion. In this diagram, the areas corresponding to the microemulsion, the liquid crystal phase, and the structural phase transition were identified. The study of the structural phase transition from the microemulsion to liquid crystal will offer a predictive power for characterizing incorporation of drugs and controlling their delivery to target cells. A deeper understanding of the structural changes is necessary to clearly determine the conditions of drug delivery

Keywords

sodium bis(2-ethylhexyl) sulfosuccinate (AOT), isopropyl myristate, NMR self-diffusion, phase transition, liquid crystal

The name of the journal

J MOL LIQ

URL

https://doi.org/10.1016/j.molliq.2024.125193

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=303873&p_lang=2

Resource files

File name	Size (MB)	Format
F_J_Mol_liq_V407_2024.pdf	3,52	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gnezdilov Oleg Ivanovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Sautina N.V. Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system/ N.V. Sautina, O.I. Gnezdilov, A.T. Gubaidullin, Yu.G. Galyametdinov// Journal of Molecular Liquids. -2024. – V.407. – 125193.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=303873&p_lang=2	ru_RU
dc.description.abstract	J MOL LIQ	ru_RU
dc.description.abstract	This work reports preparation and characterization of biocompatible sodium bis(2-ethylhexyl) sulfosuccinate (AOT) / water/ isopropyl myristate (IPM) systems. We studied their ability to form various self-organized structures such as microemulsions and liquid crystal templates for producing nanoparticles such as drug delivery vehicles, which play an important role in delivery of various substances. We determined concentration and temperature conditions that allow for forming various structures in this system and characterized the structural phase transition from the microemulsion to liquid crystalline phase, which is important for delivery of bioactive compounds. The parameters of the liquid crystalline phase of the water/AOT/isopropyl myristate system were calculated for the first time in this work. The sizes of microemulsion droplets were determined. To describe molecular motions in the studied microemulsion, self-diffusion coefficients of each component were measured. The values of relative diffusion coefficients demonstrated that reverse microemulsions were observed at AOT concentrations up to 60 % wt. Further increase in surfactant concentration slows down their molecular mobility and results in formation of aggregates with a bimodal size distribution and a subsequent formation of the hexagonal liquid crystalline phase. Geometry of the mesophase and its structure were investigated by X-ray diffraction. The respective phase diagram was plotted and analyzed using the data of polarized light microscopy, dynamic light scattering, and NMR self-diffusion. In this diagram, the areas corresponding to the microemulsion, the liquid crystal phase, and the structural phase transition were identified. The study of the structural phase transition from the microemulsion to liquid crystal will offer a predictive power for characterizing incorporation of drugs and controlling their delivery to target cells. A deeper understanding of the structural changes is necessary to clearly determine the conditions of drug delivery	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	sodium bis(2-ethylhexyl) sulfosuccinate (AOT)	ru_RU
dc.subject	isopropyl myristate	ru_RU
dc.subject	NMR self-diffusion	ru_RU
dc.subject	phase transition	ru_RU
dc.subject	liquid crystal	ru_RU
dc.title	Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system	ru_RU
dc.type	Articles in international journals and collections	ru_RU