KFU. Card publication. Changes in Contractile Characteristics of Rat Skeletal Muscles Associated with P2-Receptor Activation After Spinal Cord Transection«;« Динамика сокращений скелетных мышц крысы при активации P2-рецепторов после перерезки спинного мозга]

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CHANGES IN CONTRACTILE CHARACTERISTICS OF RAT SKELETAL MUSCLES ASSOCIATED WITH P2-RECEPTOR ACTIVATION AFTER SPINAL CORD TRANSECTION&LAQUO;;&LAQUO; ДИНАМИКА СОКРАЩЕНИЙ СКЕЛЕТНЫХ МЫШЦ КРЫСЫ ПРИ АКТИВАЦИИ P2-РЕЦЕПТОРОВ ПОСЛЕ ПЕРЕРЕЗКИ СПИННОГО МОЗГА]

Form of presentation

Articles in international journals and collections

Year of publication

2024

Язык

английский

Authors, employees of KFU

Baltin Maksim Eduardovich, author

Baltina Tatyana Valerevna, author

Grishin Sergey Nikolaevich, author

Khayrullin Adel Evgenevich, author

Other authors

Mukhamedyarov Marat Aleksandrovich, author

Authors, postgraduates KFU

Efimova Dina Vadimovna, postgraduate kfu

Bibliographic description in the original language

Khairullin A.E. Changes in Contractile Characteristics of Rat Skeletal Muscles Associated with P2-Receptor Activation After Spinal Cord Transection«;« [Dinamika sokrashheniy skeletnykh myshc krysy pri aktivacii P2-receptorov posle pererezki spinnogo mozga] /A.E. Khairullin, D.V. Efimova, M.A. Mukhamedyarov, M.E.Baltin, T.V. Baltina, S.N. Grishin. A.U. Ziganshin //Annals of Clinical and Experimental Neurology. - 2024. - Vol.18, Is.2. - P.45-51.

Annotation

We found a significant (p < 0.05) decrease in the modulating activity of ATP, as the main endogenous signaling agent, in the cholinergic synapse of the soleus muscle from 32.4 to 5.8% and from 13.7 to 5.6% for the EDL muscle after the spinalization (spinal cord injury at the Th6–Th7 level) compared with intact animals. No such dramatic changes were observed in the diaphragm. Conclusions. Abnormal ATP-mediated modulation of neuromuscular transmission demonstrated in this study supports the involvement of purinergic signaling in the neurotrophic control and functioning of various motor units. ? 2024 Research Center of Neurology. All rights reserved.

Keywords

ATPP2-receptors, post-traumatic movement, disorders, skeletal muscles, spinalization, suramin, synapse

The name of the journal

Annals of Clinical and Experimental Neurology

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199531527&doi=10.17816%2fACEN.1012&partnerID=40&md5=a2700f4e8d49883f729e68bca7186c9c

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=303354&p_lang=2

Resource files

File name	Size (MB)	Format
F_1012_35077_2_PB.pdf	0,31	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baltin Maksim Eduardovich	ru_RU
dc.contributor.author	Baltina Tatyana Valerevna	ru_RU
dc.contributor.author	Grishin Sergey Nikolaevich	ru_RU
dc.contributor.author	Khayrullin Adel Evgenevich	ru_RU
dc.contributor.author	Mukhamedyarov Marat Aleksandrovich	ru_RU
dc.contributor.author	Efimova Dina Vadimovna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Khairullin A.E. Changes in Contractile Characteristics of Rat Skeletal Muscles Associated with P2-Receptor Activation After Spinal Cord Transection«;« [Динамика сокращений скелетных мышц крысы при активации P2-рецепторов после перерезки спинного мозга] /A.E. Khairullin, D.V. Efimova, M.A. Mukhamedyarov, M.E.Baltin, T.V. Baltina, S.N. Grishin. A.U. Ziganshin //Annals of Clinical and Experimental Neurology. - 2024. - Vol.18, Is.2. - P.45-51.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=303354&p_lang=2	ru_RU
dc.description.abstract	Annals of Clinical and Experimental Neurology	ru_RU
dc.description.abstract	We found a significant (p < 0.05) decrease in the modulating activity of ATP, as the main endogenous signaling agent, in the cholinergic synapse of the soleus muscle from 32.4 to 5.8% and from 13.7 to 5.6% for the EDL muscle after the spinalization (spinal cord injury at the Th6–Th7 level) compared with intact animals. No such dramatic changes were observed in the diaphragm. Conclusions. Abnormal ATP-mediated modulation of neuromuscular transmission demonstrated in this study supports the involvement of purinergic signaling in the neurotrophic control and functioning of various motor units. ? 2024 Research Center of Neurology. All rights reserved.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ATPP2-receptors	ru_RU
dc.subject	post-traumatic movement	ru_RU
dc.subject	disorders	ru_RU
dc.subject	skeletal muscles	ru_RU
dc.subject	spinalization	ru_RU
dc.subject	suramin	ru_RU
dc.subject	synapse	ru_RU
dc.title	Changes in Contractile Characteristics of Rat Skeletal Muscles Associated with P2-Receptor Activation After Spinal Cord Transection«;« Динамика сокращений скелетных мышц крысы при активации P2-рецепторов после перерезки спинного мозга]	ru_RU
dc.type	Articles in international journals and collections	ru_RU