KFU. Card publication. Disorders of Motor Activity in a Model of Autism Spectrum Disorders

KAZAN
FEDERAL UNIVERSITY

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- 中文
- ES

DISORDERS OF MOTOR ACTIVITY IN A MODEL OF AUTISM SPECTRUM DISORDERS

Form of presentation

Articles in international journals and collections

Year of publication

2024

Язык

английский

Authors, employees of KFU

Baltin Maksim Eduardovich, author

Grishin Sergey Nikolaevich, author

Khayrullin Adel Evgenevich, author

Authors, postgraduates KFU

Efimova Dina Vadimovna, postgraduate kfu

Bibliographic description in the original language

Khairullin, A.E. Disorders of Motor Activity in a Model of Autism Spectrum Disorders / A.E. Khairullin, D.V. Efimova, D.V. Ivanova, T. V. Baltina, M. E. Baltin, S. N. Grishin A. U. Ziganshin // Neurosci Behav Physi. - 2024. - V.54. - P. 465–473. https://doi.org/10.1007/s11055-024-01613-x

Annotation

Autism, or autism spectrum disorder (ASD), is a multifactorial disease characterized not only by disturbances in psychoemotional status and social interaction, but also by somatic dysfunctions. A number of studies have also reported changes in the musculoskeletal system in patients with ASD. We report here studies using video movement analysis demonstrating decreases in horizontal and vertical motor activity; in addition, deviant movements were recorded, indicating deranged locomotor activity and increased anxiety in rats with the valproate model of autism. However, a mechano-myographic study did not reveal any significant changes in the contractility parameters of isolated skeletal muscles of rats with the model of ASD. This leads to the conclusion that general differences in movement may be an independent factor in the diagnosis of autism. A more rigorous study using a larger group and detailed kinematic analysis may help with further evaluation of motor variability as a potential diagnostic and prognostic marker for ASD.

Keywords

autism, autism spectrum disorder, ATP, P2 receptors, skeletal muscles, neuromuscular junction neurotransmission

The name of the journal

Neuroscience and Behavioral Physiology

URL

https://doi.org/10.1007/s11055-024-01613-x

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=301119&p_lang=2

Resource files

File name	Size (MB)	Format
s11055_024_01613_x.pdf	1,03	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baltin Maksim Eduardovich	ru_RU
dc.contributor.author	Grishin Sergey Nikolaevich	ru_RU
dc.contributor.author	Khayrullin Adel Evgenevich	ru_RU
dc.contributor.author	Efimova Dina Vadimovna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Khairullin, A.E. Disorders of Motor Activity in a Model of Autism Spectrum Disorders / A.E. Khairullin, D.V. Efimova, D.V. Ivanova, T. V. Baltina, M. E. Baltin, S. N. Grishin A. U. Ziganshin // Neurosci Behav Physi. - 2024. - V.54. - P. 465–473. https://doi.org/10.1007/s11055-024-01613-x	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=301119&p_lang=2	ru_RU
dc.description.abstract	Neuroscience and Behavioral Physiology	ru_RU
dc.description.abstract	Autism, or autism spectrum disorder (ASD), is a multifactorial disease characterized not only by disturbances in psychoemotional status and social interaction, but also by somatic dysfunctions. A number of studies have also reported changes in the musculoskeletal system in patients with ASD. We report here studies using video movement analysis demonstrating decreases in horizontal and vertical motor activity; in addition, deviant movements were recorded, indicating deranged locomotor activity and increased anxiety in rats with the valproate model of autism. However, a mechano-myographic study did not reveal any significant changes in the contractility parameters of isolated skeletal muscles of rats with the model of ASD. This leads to the conclusion that general differences in movement may be an independent factor in the diagnosis of autism. A more rigorous study using a larger group and detailed kinematic analysis may help with further evaluation of motor variability as a potential diagnostic and prognostic marker for ASD.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	autism	ru_RU
dc.subject	autism spectrum disorder	ru_RU
dc.subject	ATP	ru_RU
dc.subject	P2 receptors	ru_RU
dc.subject	skeletal muscles	ru_RU
dc.subject	neuromuscular junction neurotransmission	ru_RU
dc.title	Disorders of Motor Activity in a Model of Autism Spectrum Disorders	ru_RU
dc.type	Articles in international journals and collections	ru_RU