KFU. Card publication. Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study

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FEDERAL UNIVERSITY

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PREDICTIVE RISK FACTORS BEFORE THE ONSET OF FAMILIAL RHEUMATOID ARTHRITIS: THE TATARSTAN COHORT STUDY

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Kravcova Olga Aleksandrovna, author

Novikov Andrey Andreevich, author

Shagimardanova Elena Ilyasovna, author

Bibliographic description in the original language

Arleevskaya M.I, Larionova R.V, Shagimardanova E.I, Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study//Frontiers in Medicine. - 2023. - Vol.10, Is.. - Art. �1227786.

Annotation

Background: A familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort. Methods: A total of 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2–21 years) before conversion to RA and compared to non-converted 328 first-degree relatives (FDR) from RA as assessed after ≥2 years follow-up, and 355 healthy controls were also selected (HC). Preclinical parameters and socio-demographic/individual/HLA genetic factors were analyzed when data were available at the time of enrollment. Results: As compared to FDR and HC groups, pre-RA individuals were characterized before conversion to RA by the presence of arthralgia, severe morning symptoms, a lower educational level, and rural location. An association with the HLA-DRB1 SE risk factor was also retrieved with symmetrical arthralgia and passive smoking. On the contrary, alcohol consumption and childlessness in women were protective and associated with the HLA-DRB1*07:01 locus. Conclusion: Before RA onset, a combination of individual and genetic factors characterized those who are at risk of progressing to RA among those with familial RA relatives.

Keywords

familial rheumatoid arthritis, risk factors, shared epitope, low education, symmetrical arthralgia, childless

The name of the journal

FRONTIERS IN MEDICINE

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174967552&doi=10.3389%2ffmed.2023.1227786&partnerID=40&md5=2c6c74552dea7f70fd9939511629d910

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=298607&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kravcova Olga Aleksandrovna	ru_RU
dc.contributor.author	Novikov Andrey Andreevich	ru_RU
dc.contributor.author	Shagimardanova Elena Ilyasovna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Arleevskaya M.I, Larionova R.V, Shagimardanova E.I, Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study//Frontiers in Medicine. - 2023. - Vol.10, Is.. - Art. �1227786.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=298607&p_lang=2	ru_RU
dc.description.abstract	FRONTIERS IN MEDICINE	ru_RU
dc.description.abstract	Background: A familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort. Methods: A total of 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2–21 years) before conversion to RA and compared to non-converted 328 first-degree relatives (FDR) from RA as assessed after ≥2 years follow-up, and 355 healthy controls were also selected (HC). Preclinical parameters and socio-demographic/individual/HLA genetic factors were analyzed when data were available at the time of enrollment. Results: As compared to FDR and HC groups, pre-RA individuals were characterized before conversion to RA by the presence of arthralgia, severe morning symptoms, a lower educational level, and rural location. An association with the HLA-DRB1 SE risk factor was also retrieved with symmetrical arthralgia and passive smoking. On the contrary, alcohol consumption and childlessness in women were protective and associated with the HLA-DRB1*07:01 locus. Conclusion: Before RA onset, a combination of individual and genetic factors characterized those who are at risk of progressing to RA among those with familial RA relatives.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	familial rheumatoid arthritis	ru_RU
dc.subject	risk factors	ru_RU
dc.subject	shared epitope	ru_RU
dc.subject	low education	ru_RU
dc.subject	symmetrical arthralgia	ru_RU
dc.subject	childless	ru_RU
dc.title	Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study	ru_RU
dc.type	Articles in international journals and collections	ru_RU