KFU. Card publication. DISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERS

KAZAN
FEDERAL UNIVERSITY

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- 中文
- ES

DISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERS

Form of presentation

Articles in international journals and collections

Year of publication

2023

Язык

английский

Authors, employees of KFU

Baltin Maksim Eduardovich, author

Baltina Tatyana Valerevna, author

Grishin Sergey Nikolaevich, author

Efimova Dina Vadimovna, author

Khayrullin Adel Evgenevich, author

Other authors

Ziganshin Ayrat Usmanovich, author

Authors, postgraduates KFU

Efimova Dina Vadimovna, postgraduate kfu

Bibliographic description in the original language

Khairumn A.E. DISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERS/A.E.Khairumn, D.V. Efimova, D.V. Ivanova, T.V. Baltina, M.E. Baltin, S.N. Grishin, A.U. Ziganshin // Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. - 2023. - Vol.73, Is.6. - P.819-832.

Annotation

Autism, or autism spectrum disorder (ASD), is a multifactorial disease that is characterized not only by disorders of the psycho-emotional state and social interaction, but also by somatic dysfunctions. A number of studies have also reported changes in the musculoskeletal system in patients with ASD. In this work, by the method of video analysis of movements, we demonstrated a decrease in horizontal and vertical motor activity, in addition, deviant movements were recorded, which indicates a violation in locomotor activity and increased anxiety in rats with a valproate model of autism. However, a mechano-myographic study did not reveal significant changes in the contractility parameters of isolated skeletal muscles of rats with the ASD model. Thus, it can be concluded that general differences in movement may be an independent factor in the diagnosis of autism. A more thorough study using a larger sample and detailed kinematic analysis can help in further assessing the variability of motor functions as a potential diagnostic and prognostic marker of ASD.

Keywords

ATP, autismautism spectrum disorders, neuromuscular synapse, neurotransmission, P2 receptors, skeletal muscles

The name of the journal

Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188214068&doi=10.31857%2fS0044467723060047&partnerID=40&md5=999a0452bbb645b29f10d6326d644a55

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=297395&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baltin Maksim Eduardovich	ru_RU
dc.contributor.author	Baltina Tatyana Valerevna	ru_RU
dc.contributor.author	Grishin Sergey Nikolaevich	ru_RU
dc.contributor.author	Efimova Dina Vadimovna	ru_RU
dc.contributor.author	Khayrullin Adel Evgenevich	ru_RU
dc.contributor.author	Ziganshin Ayrat Usmanovich	ru_RU
dc.contributor.author	Efimova Dina Vadimovna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Khairumn A.E. DISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERS/A.E.Khairumn, D.V. Efimova, D.V. Ivanova, T.V. Baltina, M.E. Baltin, S.N. Grishin, A.U. Ziganshin // Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. - 2023. - Vol.73, Is.6. - P.819-832.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=297395&p_lang=2	ru_RU
dc.description.abstract	Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova	ru_RU
dc.description.abstract	Autism, or autism spectrum disorder (ASD), is a multifactorial disease that is characterized not only by disorders of the psycho-emotional state and social interaction, but also by somatic dysfunctions. A number of studies have also reported changes in the musculoskeletal system in patients with ASD. In this work, by the method of video analysis of movements, we demonstrated a decrease in horizontal and vertical motor activity, in addition, deviant movements were recorded, which indicates a violation in locomotor activity and increased anxiety in rats with a valproate model of autism. However, a mechano-myographic study did not reveal significant changes in the contractility parameters of isolated skeletal muscles of rats with the ASD model. Thus, it can be concluded that general differences in movement may be an independent factor in the diagnosis of autism. A more thorough study using a larger sample and detailed kinematic analysis can help in further assessing the variability of motor functions as a potential diagnostic and prognostic marker of ASD.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ATP	ru_RU
dc.subject	autismautism spectrum disorders	ru_RU
dc.subject	neuromuscular synapse	ru_RU
dc.subject	neurotransmission	ru_RU
dc.subject	P2 receptors	ru_RU
dc.subject	skeletal muscles	ru_RU
dc.title	DISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERS	ru_RU
dc.type	Articles in international journals and collections	ru_RU