KFU. Card publication. Dimephosphone analogs: A pharmacological aspect

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FEDERAL UNIVERSITY

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DIMEPHOSPHONE ANALOGS: A PHARMACOLOGICAL ASPECT

Form of presentation

Articles in international journals and collections

Year of publication

2014

Язык

английский

Authors, employees of KFU

Kashapov Lenar Ramilovich, author

Bibliographic description in the original language

Dimephosphone analogs: A pharmacological aspect / V. F. Mironov, B. I. Buzykin, D. A. Tatarinov [et al.] // Russian Chemical Bulletin. – 2014. – Vol. 63, No. 9. – P. 2114-2125. – DOI 10.1007/s11172-014-0708-2. – EDN UGGDMR.

Annotation

We studied some pharmacological properties of dimephosphone P - C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P - O - C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P - C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.

Keywords

4-NITROBENZHYDRAZIDE, ACUTE TOXICITY, ACYL HYDRAZONE, ANTI-INFLAMMATORY ACTIVITY, ANTITUBERCULOUS ACTIVITY, AROYL HYDRAZONE, BENZHYDRAZIDE, BIOACTIVITY, DIMEPHOSPHONE, DIMETHYL (2-METHYL-4-OXOPENT-2-YL)PHOSPHONATE, ISONIAZIDE, ISONICOTINOYL HYDRAZONE, NICOTINIC ACID HYDRAZIDE, NICOTINOYL HYDRAZONE, OXIME, PHOSPHINE OXIDE, PYRIDINOYL HYDRAZONE

The name of the journal

Russian Chemical Bulletin

URL

https://link.springer.com/article/10.1007/s11172-014-0708-2

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=296902&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kashapov Lenar Ramilovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Dimephosphone analogs: A pharmacological aspect / V. F. Mironov, B. I. Buzykin, D. A. Tatarinov [et al.] // Russian Chemical Bulletin. – 2014. – Vol. 63, No. 9. – P. 2114-2125. – DOI 10.1007/s11172-014-0708-2. – EDN UGGDMR.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=296902&p_lang=2	ru_RU
dc.description.abstract	Russian Chemical Bulletin	ru_RU
dc.description.abstract	We studied some pharmacological properties of dimephosphone P - C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P - O - C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P - C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	4-NITROBENZHYDRAZIDE	ru_RU
dc.subject	ACUTE TOXICITY	ru_RU
dc.subject	ACYL HYDRAZONE	ru_RU
dc.subject	ANTI-INFLAMMATORY ACTIVITY	ru_RU
dc.subject	ANTITUBERCULOUS ACTIVITY	ru_RU
dc.subject	AROYL HYDRAZONE	ru_RU
dc.subject	BENZHYDRAZIDE	ru_RU
dc.subject	BIOACTIVITY	ru_RU
dc.subject	DIMEPHOSPHONE	ru_RU
dc.subject	DIMETHYL (2-METHYL-4-OXOPENT-2-YL)PHOSPHONATE	ru_RU
dc.subject	ISONIAZIDE	ru_RU
dc.subject	ISONICOTINOYL HYDRAZONE	ru_RU
dc.subject	NICOTINIC ACID HYDRAZIDE	ru_RU
dc.subject	NICOTINOYL HYDRAZONE	ru_RU
dc.subject	OXIME	ru_RU
dc.subject	PHOSPHINE OXIDE	ru_RU
dc.subject	PYRIDINOYL HYDRAZONE	ru_RU
dc.title	Dimephosphone analogs: A pharmacological aspect	ru_RU
dc.type	Articles in international journals and collections	ru_RU