KFU. Card publication. Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

SYNTHESIS AND STRUCTURE OF DIMEPHOSPHONE PYRIDINOYLHYDRAZONES WITH ANTIMYCOBACTERIAL ACTIVITY

Form of presentation

Articles in international journals and collections

Year of publication

2013

��

��

Authors, employees of KFU

Kashapov Lenar Ramilovich, author

Other authors

Garaev Ramil Sufiakhmetovich, author

Bibliographic description in the original language

Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity / B. I. Buzykin, V. N. Nabiullin, V. F. Mironov [et al.] // Pharmaceutical Chemistry Journal. – 2013. – Vol. 47, No. 1. – P. 35-39. – DOI 10.1007/s11094-013-0891-8. – EDN RFGJVV.

Annotation

Nicotinoyl- and isonicotinoylhydrazones of 2-dimethoxyphosphoryl-2- methylpentan-4-one (the active ingredient of the medicinal preparation Dimephosphone) were synthesized. It was shown that crystals of both hydrazones contained a single spatial form of the EC=N isomer. The dimephosphone pyridinoylhydrazones existed in slightly polar and polar solvents as a mixture of two amide conformers of a single EC=N isomer. This was due to hindered rotation of the molecular fragments around the (O=)C-N amide bond. The ratio of conformers was determined by the solvent and the time of solution preparation. Both hydrazones possessed low toxicity and high antimycobacterial activity. ? 2013 Springer Science+Business Media New York.

Keywords

AMIDE CONFORMERS, ANTITUBERCULOSIS ACTIVITY, BIOLOGICAL ACTIVITY, DIMEPHOSPHONE ISO-NICOTINOYLHYDRAZONE, DIMEPHOSPHONE NICOTINOYLHYDRAZONE, DIMEPHOSPHONE PYRIDINOYLHYDRAZONES, GEOMETRIC ISOMERS, IR SPECTROSCOPY, NMR SPECTROSCOPY, STRUCTURE OF ACYLHYDRAZONES, TOXICITY

The name of the journal

Pharmaceutical Chemistry Journal

URL

https://link.springer.com/article/10.1007/s11094-013-0891-8

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=296901&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kashapov Lenar Ramilovich	ru_RU
dc.contributor.author	Garaev Ramil Sufiakhmetovich	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity / B. I. Buzykin, V. N. Nabiullin, V. F. Mironov [et al.] // Pharmaceutical Chemistry Journal. – 2013. – Vol. 47, No. 1. – P. 35-39. – DOI 10.1007/s11094-013-0891-8. – EDN RFGJVV.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=296901&p_lang=2	ru_RU
dc.description.abstract	Pharmaceutical Chemistry Journal	ru_RU
dc.description.abstract	Nicotinoyl- and isonicotinoylhydrazones of 2-dimethoxyphosphoryl-2- methylpentan-4-one (the active ingredient of the medicinal preparation Dimephosphone) were synthesized. It was shown that crystals of both hydrazones contained a single spatial form of the EC=N isomer. The dimephosphone pyridinoylhydrazones existed in slightly polar and polar solvents as a mixture of two amide conformers of a single EC=N isomer. This was due to hindered rotation of the molecular fragments around the (O=)C-N amide bond. The ratio of conformers was determined by the solvent and the time of solution preparation. Both hydrazones possessed low toxicity and high antimycobacterial activity. ? 2013 Springer Science+Business Media New York.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	AMIDE CONFORMERS	ru_RU
dc.subject	ANTITUBERCULOSIS ACTIVITY	ru_RU
dc.subject	BIOLOGICAL ACTIVITY	ru_RU
dc.subject	DIMEPHOSPHONE ISO-NICOTINOYLHYDRAZONE	ru_RU
dc.subject	DIMEPHOSPHONE NICOTINOYLHYDRAZONE	ru_RU
dc.subject	DIMEPHOSPHONE PYRIDINOYLHYDRAZONES	ru_RU
dc.subject	GEOMETRIC ISOMERS	ru_RU
dc.subject	IR SPECTROSCOPY	ru_RU
dc.subject	NMR SPECTROSCOPY	ru_RU
dc.subject	STRUCTURE OF ACYLHYDRAZONES	ru_RU
dc.subject	TOXICITY	ru_RU
dc.title	Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity	ru_RU
dc.type	Articles in international journals and collections	ru_RU