KFU. Card publication. New Polymorph of β-Cyclodextrin with a Higher Bioavailability

KAZAN
FEDERAL UNIVERSITY

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NEW POLYMORPH OF β-CYCLODEXTRIN WITH A HIGHER BIOAVAILABILITY

Form of presentation

Articles in international journals and collections

Year of publication

2024

Язык

английский

Authors, employees of KFU

Balakhoncev Ilya Sergeevich, author

Gatiatulin Askar Kamilevich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Authors, students KFU

Talashmanova Sofya Mikhaylovna, author

Bibliographic description in the original language

Gatiatulin, A.K.; Balakhontsev, I.S.; Talashmanova, S.M.; Ziganshin, M.A.; Gorbatchuk, V.V. New Polymorph of β-Cyclodextrin with a Higher Bioavailability. Chemistry 2024, 6, 51-61. https://doi.org/10.3390/chemistry6010003

Annotation

A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis. The solution enthalpy and time of dissolution in water were determined using solution calorimetry for this polymorph and compared with those of the dried commercial form of β-cyclodextrin (polymorph I), its amorphous form, and 2-hydroxypropyl-β-cyclodextrin. The specific heat capacities of polymorphs I and III were determined using differential scanning calorimetry across a wide range of temperatures, providing enthalpy and Gibbs energy values for the polymorphic transition at 298 K. The affinities of polymorph III and 2-hydroxypropyl-β-cyclodextrin for water were characterized by determining their hydration isotherms, which provided values of hydration Gibbs energy. Being energy-rich, the new-found polymorph of β-cyclodextrin has a significantly higher dissolution rate and an increased affinity for water compared with the dried commercial form of β-cyclodextrin. These properties render the new polymorph promising in industrial applications for guest inclusion in aqueous solutions and pastes, and may be a desirable alternative for water-soluble β-cyclodextrin derivatives.

Keywords

beta-cyclodextrin, polymorphism, bioavailability, polymorphic transition, dissolution rate

The name of the journal

Chemistry

URL

https://www.mdpi.com/2624-8549/6/1/3

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=296196&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Balakhoncev Ilya Sergeevich	ru_RU
dc.contributor.author	Gatiatulin Askar Kamilevich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Talashmanova Sofya Mikhaylovna	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Gatiatulin, A.K.; Balakhontsev, I.S.; Talashmanova, S.M.; Ziganshin, M.A.; Gorbatchuk, V.V. New Polymorph of β-Cyclodextrin with a Higher Bioavailability. Chemistry 2024, 6, 51-61. https://doi.org/10.3390/chemistry6010003	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=296196&p_lang=2	ru_RU
dc.description.abstract	Chemistry	ru_RU
dc.description.abstract	A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis. The solution enthalpy and time of dissolution in water were determined using solution calorimetry for this polymorph and compared with those of the dried commercial form of β-cyclodextrin (polymorph I), its amorphous form, and 2-hydroxypropyl-β-cyclodextrin. The specific heat capacities of polymorphs I and III were determined using differential scanning calorimetry across a wide range of temperatures, providing enthalpy and Gibbs energy values for the polymorphic transition at 298 K. The affinities of polymorph III and 2-hydroxypropyl-β-cyclodextrin for water were characterized by determining their hydration isotherms, which provided values of hydration Gibbs energy. Being energy-rich, the new-found polymorph of β-cyclodextrin has a significantly higher dissolution rate and an increased affinity for water compared with the dried commercial form of β-cyclodextrin. These properties render the new polymorph promising in industrial applications for guest inclusion in aqueous solutions and pastes, and may be a desirable alternative for water-soluble β-cyclodextrin derivatives.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	beta-cyclodextrin	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	bioavailability	ru_RU
dc.subject	polymorphic transition	ru_RU
dc.subject	dissolution rate	ru_RU
dc.title	New Polymorph of β-Cyclodextrin with a Higher Bioavailability	ru_RU
dc.type	Articles in international journals and collections	ru_RU