KFU. Card publication. Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy

- RUS
- 中文
- ES

PHOTO- AND X-RAY INDUCED CYTOTOXICITY OF CEF3-YF3-TBF3 NANOPARTICLE-POLYVINYLPYRROLIDONE&MDASH;&LDQUO;RADACHLORIN&RDQUO; COMPOSITES FOR COMBINED PHOTODYNAMIC THERAPY

Form of presentation

Articles in international journals and collections

Year of publication

2024

��

��

Authors, employees of KFU

Zinchenko Sergey Viktorovich, author

Safin Damir Ilyasovich, author

Bibliographic description in the original language

Khusainova, A.I.Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy / A.I. Khusainova, A.S. Nizamutdinov, N.I. Shamsutdinov, S.Kalinichenko, D.I. Safin, M. Gafurov, E.V. Lukinova, S.Kh. Batygov, S. V. Kuznetsov, S.V. Zinchenko, P.V. Zelenikhin, M. Pudovkin // Materials.- 2024, -�17, 316.-z.1-14

Annotation

The Ce0.5Y0.35Tb0.15F3 nanoparticles with a CeF3 hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ? 1 nm. The luminescence decay curves of the Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4– 7F5 transition of Tb3+) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was R0 = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%.

Keywords

photodynamic therapy; combined photodynamic therapy; Radachlorin; nanoparticlephotosensitizer conjugates

The name of the journal

Materials

URL

https://doi.org/10.3390/ma17020316

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=294070&p_lang=2

Resource files

File name	Size (MB)	Format
F_materials_17_00316_v2.pdf	5,25	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zinchenko Sergey Viktorovich	ru_RU
dc.contributor.author	Safin Damir Ilyasovich	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Khusainova, A.I.Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy / A.I. Khusainova, A.S. Nizamutdinov, N.I. Shamsutdinov, S.Kalinichenko, D.I. Safin, M. Gafurov, E.V. Lukinova, S.Kh. Batygov, S. V. Kuznetsov, S.V. Zinchenko, P.V. Zelenikhin, M. Pudovkin // Materials.- 2024, -�17, 316.-�.1-14	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=294070&p_lang=2	ru_RU
dc.description.abstract	Materials	ru_RU
dc.description.abstract	The Ce0.5Y0.35Tb0.15F3 nanoparticles with a CeF3 hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ? 1 nm. The luminescence decay curves of the Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4– 7F5 transition of Tb3+) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was R0 = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Photo- and X-ray Induced Cytotoxicity of CeF3-YF3-TbF3 Nanoparticle-Polyvinylpyrrolidone—“Radachlorin” Composites for Combined Photodynamic Therapy	ru_RU
dc.type	Articles in international journals and collections	ru_RU