KFU. Card publication. CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study)

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CD38 GENE POLYMORPHISM RS1130169 CONTRIBUTION TO THE INCREASED GENE EXPRESSION AND RISK OF COLORECTAL CANCER (PILOT STUDY)

Form of presentation

Articles in international journals and collections

Year of publication

2024

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Authors, employees of KFU

Kubysheva Nailya Iskhakovna, author

Other authors

Novikov Dmitry , author

Novikov Viktor , author

Perenkov Alexei , author

Shumilova Svetlana , author

Bibliographic description in the original language

Novikov, D. V., Perenkov, A. D., Shumilova, S. V., Kubysheva, N. I., & Novikov, V. V. (2024). CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study). Molecular Biology Reports, 51(1), 1-8.

Annotation

Molecular Biology Reports

Keywords

CD38; mRNA expression; single nucleotide polymorphism; colorectal cancer

The name of the journal

Molecular Biology Reports

URL

https://link.springer.com/article/10.1007/s11033-023-09034-8

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=294010&p_lang=2

Resource files

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CD38_gene_polymorphism_rs1130169_contribution_to_the_increased_gene_expression_of_colorectal_cancer.pdf	0,74	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kubysheva Nailya Iskhakovna	ru_RU
dc.contributor.author	Novikov Dmitry	ru_RU
dc.contributor.author	Novikov Viktor	ru_RU
dc.contributor.author	Perenkov Alexei	ru_RU
dc.contributor.author	Shumilova Svetlana	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Novikov, D. V., Perenkov, A. D., Shumilova, S. V., Kubysheva, N. I., & Novikov, V. V. (2024). CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study). Molecular Biology Reports, 51(1), 1-8.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=294010&p_lang=2	ru_RU
dc.description.abstract	Molecular Biology Reports	ru_RU
dc.description.abstract	Background Genetic variations in immune signaling genes may have regulatory effect on phenotypic heterogeneity of immune cells and immune functions, hence promoting tumor growth. Purpose We compared the frequencies of potentially functional CD38 gene single nucleotide polymorphisms rs1130169 (T>C) in 86 healthy controls and 90 colorectal cancer (CRC) cases to assess their association with cancer risk and CD38 gene expression. Results The association between allele C rs1130169 and CRC risk was observed. Allele C was also significantly correlated with an increased CD38 mRNA level and CD38 positive cell percentages in peripheral blood of healthy controls that could be a possible explanation for CRC risk in C allele carriers. In peripheral blood of CRC patients CD38 mRNA and serum soluble CD38 protein levels significantly differed from those in healthy controls. Calculation of the CD38 full-length and with the third exon deletion mRNA ratio in corresponding samples showed that the mRNA isoform ratio was significantly higher in CRC cases than in controls. It suggests that alternative splicing regulates elevation of CD38 full-length mRNA level in peripheral blood of CRC patients. We also have observed higher expression levels of CD38 full-length mRNA in peripheral blood of CRC patients with lymph node metastases compared to patients without metastases. Conclusion This study indicated biological significance of rs1130169 variations that can alter differences in CRC risk by regulating CD38 gene expression.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study)	ru_RU
dc.type	Articles in international journals and collections	ru_RU