KFU. Card publication. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal Stem Cells

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FEDERAL UNIVERSITY

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FEATURES OF INDUCTION OF IN VITRO OSTEODIFFERENTIATION OF ADIPOSE-DERIVED MESENCHYMAL STEM CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Aymaletdinov Aleksandr Maazovich, author

Aleksandrova Natalya Mikhaylovna, author

Zakirova Elena Yurevna, author

Malaneva Albina Gennadevna, author

Rizvanov Albert Anatolevich, author

Bibliographic description in the original language

Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G. et al. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal / Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G., Rizvanov A.A., Zakirova E.Yu. // Stem Cells. Appl Biochem Microbiol. - 2023. - �59. - r. 1071–1077.

Annotation

Appl Biochem Microbiol

Keywords

�esenchymal stem cells, osteodifferentiation, bone morphogenetic protein.

The name of the journal

Appl Biochem Microbiol

URL

https://link.springer.com/article/10.1134/S0003683823080021#citeas

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=293164&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aymaletdinov Aleksandr Maazovich	ru_RU
dc.contributor.author	Aleksandrova Natalya Mikhaylovna	ru_RU
dc.contributor.author	Zakirova Elena Yurevna	ru_RU
dc.contributor.author	Malaneva Albina Gennadevna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G. et al. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal / Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G., Rizvanov A.A., Zakirova E.Yu. // Stem Cells. Appl Biochem Microbiol. - 2023. - �59. - �. 1071–1077.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=293164&p_lang=2	ru_RU
dc.description.abstract	Appl Biochem Microbiol	ru_RU
dc.description.abstract	The features of osteogenic differentiation of mesenchymal stem cells (MSCs) of dogs, native and genetically modified, have been compared when cultivated in different media. It was shown that calcium deposition into the extracellular matrix occurred within 21 day of cultivation of MSCs on a commercial induction medium. The use of α-MEM-based medium, which contains osteoinducing components, also caused osteogenic differentiation of MSCs, but calcium deposition was less active. Gene modification of canine MSCs with a plasmid carrying the gene for canine (Canis familiaris) bone morphogenetic protein 2 gene (BMP2) stimulated the release of alkaline phosphatase by cells, but not calcium deposition. Consequently, the formation of osteocytes from MSCs depends not only on endogenous, but also exogenous factors, which include dexamethasone in combination with ascorbic acid and β-glycerophosphate, and full osteogenic differentiation of MSCs in vitro requires many osteoinductive factors.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	�esenchymal stem cells	ru_RU
dc.subject	osteodifferentiation	ru_RU
dc.subject	bone morphogenetic protein.	ru_RU
dc.title	Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal Stem Cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU