KFU. Card publication. Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone

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FEDERAL UNIVERSITY

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MAGNETIC RESONANCE-BASED ANALYTICAL TOOLS TO STUDY POLYVINYLPYRROLIDONE&NDASH;HYDROXYAPATITE COMPOSITES

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Gnezdilov Oleg Ivanovich, author

Other authors

Antoniac Iulian V., author

Rau Julietta V., author

Bibliographic description in the original language

Petrova A. Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites / Alina Petrova, Georgy Mamin, Oleg Gnezdilov, Inna Fadeeva, Olga Antonova, Anna Forysenkova, Iulian V. Antoniac, Julietta V. Rau and Marat Gafurov// Polymers. – 2023. – N.15. - 4445.

Annotation

The synthesis of biocompatible and bioresorbable composite materials, such as a “polymer matrix-mineral constituent,” stimulating the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine and materials science. Composite films of bioresorbable polymer of polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) were obtained. HA was synthesized in situ in the polymer solution. We applied electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) approaches to study the composite films' properties. The application of EPR in two frequency ranges allowed us to derive spectroscopic parameters of the nitrogen-based light and radiation-induced paramagnetic centers in HA, PVP and PVP-HA with high accuracy. It was shown that PVP did not significantly affect the EPR spectral and relaxation parameters of the radiation-induced paramagnetic centers in HA, while light-induced centers were detected only in PVP. Magic angle spinning (MAS) 1H NMR showed the presence of two signals at 4.7 ppm and −2.15 ppm, attributed to “free” water and hydroxyl groups, while the single line was attributed to 31P. NMR relaxation measurements for 1H and 31P showed that the relaxation decays were multicomponent processes that can be described by three components of the transverse relaxation times. The obtained results demonstrated that the applied magnetic resonance methods can be used for the quality control of PVP-HA composites and, potentially, for the development of analytical tools to follow the processes of sample treatment, resorption, and degradation.

Keywords

Magnetic Resonance, Hydroxyapatite, NMR relaxation, Polyvinylpyrrolidone

The name of the journal

POLYMERS

URL

https://doi.org/10.3390/polym15224445

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=291601&p_lang=2

Resource files

File name	Size (MB)	Format
polymers_15_04445.pdf	3,71	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gnezdilov Oleg Ivanovich	ru_RU
dc.contributor.author	Antoniac Iulian V.	ru_RU
dc.contributor.author	Rau Julietta V.	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Petrova A. Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites / Alina Petrova, Georgy Mamin, Oleg Gnezdilov, Inna Fadeeva, Olga Antonova, Anna Forysenkova, Iulian V. Antoniac, Julietta V. Rau and Marat Gafurov// Polymers. – 2023. – N.15. - 4445.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=291601&p_lang=2	ru_RU
dc.description.abstract	POLYMERS	ru_RU
dc.description.abstract	The synthesis of biocompatible and bioresorbable composite materials, such as a “polymer matrix-mineral constituent,” stimulating the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine and materials science. Composite films of bioresorbable polymer of polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) were obtained. HA was synthesized in situ in the polymer solution. We applied electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) approaches to study the composite films' properties. The application of EPR in two frequency ranges allowed us to derive spectroscopic parameters of the nitrogen-based light and radiation-induced paramagnetic centers in HA, PVP and PVP-HA with high accuracy. It was shown that PVP did not significantly affect the EPR spectral and relaxation parameters of the radiation-induced paramagnetic centers in HA, while light-induced centers were detected only in PVP. Magic angle spinning (MAS) 1H NMR showed the presence of two signals at 4.7 ppm and −2.15 ppm, attributed to “free” water and hydroxyl groups, while the single line was attributed to 31P. NMR relaxation measurements for 1H and 31P showed that the relaxation decays were multicomponent processes that can be described by three components of the transverse relaxation times. The obtained results demonstrated that the applied magnetic resonance methods can be used for the quality control of PVP-HA composites and, potentially, for the development of analytical tools to follow the processes of sample treatment, resorption, and degradation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Magnetic Resonance	ru_RU
dc.subject	Hydroxyapatite	ru_RU
dc.subject	NMR relaxation	ru_RU
dc.subject	Polyvinylpyrrolidone	ru_RU
dc.title	Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites	ru_RU
dc.type	Articles in international journals and collections	ru_RU