KFU. Card publication. Artificial Microvesicles: New Perspective on Healing Tendon Wounds.

KAZAN
FEDERAL UNIVERSITY

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ARTIFICIAL MICROVESICLES: NEW PERSPECTIVE ON HEALING TENDON WOUNDS.

Form of presentation

Articles in international journals and collections

Year of publication

2023

Язык

английский

Authors, employees of KFU

Aymaletdinov Aleksandr Maazovich, author

Zakirova Elena Yurevna, author

Malaneva Albina Gennadevna, author

Mansurova Milana Nikolaevna, author

Rizvanov Albert Anatolevich, author

Titova Angelina Andreevna, author

Other authors

Rutland Catrin , author

Authors, students KFU

Kurilov Igor Vitalevich, author

Yuferova Alina Konstantinovna, author

Bibliographic description in the original language

Zakirova E., Aimaletdinov A. , Mansurova M., Titova A., Kurilov I., Rutland C., Malanyeva A., Rizvanov A. Artificial Microvesicles: New Perspective on Healing Tendon Wounds. Cells Tissues Organs 2022. https://doi.org/10.1159/000526845

Annotation

Cells Tissues Organs

Keywords

Tendon, Stem/progenitor cell, Microvesicle, Differentiation, Membrane fusion

The name of the journal

Cells Tissues Organs

URL

https://karger.com/cto/article-abstract/doi/10.1159/000526845/836950/Artificial-Microvesicles-New-Perspective-on?redirectedFrom=fulltext

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=288139&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aymaletdinov Aleksandr Maazovich	ru_RU
dc.contributor.author	Zakirova Elena Yurevna	ru_RU
dc.contributor.author	Malaneva Albina Gennadevna	ru_RU
dc.contributor.author	Mansurova Milana Nikolaevna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Titova Angelina Andreevna	ru_RU
dc.contributor.author	Rutland Catrin	ru_RU
dc.contributor.author	Kurilov Igor Vitalevich	ru_RU
dc.contributor.author	Yuferova Alina Konstantinovna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Zakirova E., Aimaletdinov A. , Mansurova M., Titova A., Kurilov I., Rutland C., Malanyeva A., Rizvanov A. Artificial Microvesicles: New Perspective on Healing Tendon Wounds. Cells Tissues Organs 2022. https://doi.org/10.1159/000526845	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=288139&p_lang=2	ru_RU
dc.description.abstract	Cells Tissues Organs	ru_RU
dc.description.abstract	Tendons have a limited capacity to repair both naturally and following clinical interventions. Damaged tissue often presents with structural and functional differences, adversely affecting animal performance, mobility, health, and welfare. Advances in cell therapies have started to overcome some of these issues, however complications such as the formation of ectopic bone remain a complication of this technique. Regenerative medicine is therefore looking toward future therapies such as the introduction of microvesicles (MVs) derived from stem cells (SCs). The aim of the present study was to assess the characteristics of artificially derived MVs, from equine mesenchymal stem cells (MSCs), when delivered to rat tendon cells in vitro and damaged tendons in vivo. The initial stages of extracting MVs from equine MSCs and identifying and characterizing the cultured tendon stem/progenitor cells (TSCs) from rat Achilles tendons were undertaken successfully. The horse MSCs and the rat tendon cells were both capable of differentiating in 3 directions: adipogenic, osteogenic, and chondrogenic pathways. The artificially derived equine MVs successfully fused with the TSC membranes, and no cytotoxic or cytostimulating effects were observed. In addition, co-cultivation of TSCs with MVs led to stimulation of cell proliferation and migration, and cytokine VEGF and fractalkine expression levels were significantly increased. These experiments are the first to show that artificially derived MVs exhibited regeneration-stimulating effects in vitro, and that fusion of cytoplasmic membranes from diploid cell lines originating from different species was possible. The experiment in vivo demonstrated the influence of MVs on synthesis of collagen I and III types in damaged tendons of rats. Explorations in vivo showed accelerated regeneration of injured tendons after introduction of the MVs into damaged areas. The results from the studies performed indicated obvious positive modifying effects following the administration of MVs. This represents the initial successful step required prior to translating this regenerative medicine technique into clinical trials, such as for tendon repair in injured horses.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Tendon	ru_RU
dc.subject	Stem/progenitor cell	ru_RU
dc.subject	Microvesicle	ru_RU
dc.subject	Differentiation	ru_RU
dc.subject	Membrane fusion	ru_RU
dc.title	Artificial Microvesicles: New Perspective on Healing Tendon Wounds.	ru_RU
dc.type	Articles in international journals and collections	ru_RU