KFU. Card publication. New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry

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NEW POLYMORPH OF INDOMETHACIN: SCREENING BY SOLID-STATE GUEST EXCHANGE AND CHARACTERIZATION USING FAST SCANNING CALORIMETRY

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Buzyurov Aleksey Vladimirovich, author

Gataullina Karina Vsevolodovna, author

Gatiatulin Askar Kamilevich, author

Gerasimov Aleksandr Vladimirovich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Shik Kristof Erik Georg , author

Bibliographic description in the original language

Gataullina K. V; Buzyurov A. V; Gerasimov A. V; Gatiatulin A. K.; Ziganshin M. A.; Schick C.; Gorbatchuk V. V. New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry. // Cryst. Growth Des. — 2023. DOI: 10.1021/acs.cgd.3c00443

Annotation

Solid-state guest exchange is used as an efficient method to prepare very metastable polymorphs of indomethacin, including the polymorph observed earlier only in a mixture with a polymeric solvent and a new crystalline form of this drug with a negligibly small amount of the included solvent (guest). The used preparation procedure gives less stable inclusion compounds of indomethacin, which require a milder desolvation treatment than inclusion compounds formed in binary host−guest systems, so the metastable forms with a low first melting point can be prepared. For the characterization of indomethacin polymorphs, fast scanning calorimetry was used, along with conventional characterization methods. This method merges multistep polymorphic transitions, making the first melting point much more pronounced, so the different polymorphs become better discriminated.

Keywords

indomethacin, polymorphism, pseudopolymorphism, inclusion compound, fast scanning calorimetry

The name of the journal

CRYSTAL GROWTH & DESIGN

URL

https://pubs.acs.org/doi/10.1021/acs.cgd.3c00443

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=285563&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Buzyurov Aleksey Vladimirovich	ru_RU
dc.contributor.author	Gataullina Karina Vsevolodovna	ru_RU
dc.contributor.author	Gatiatulin Askar Kamilevich	ru_RU
dc.contributor.author	Gerasimov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Shik Kristof Erik Georg	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Gataullina K. V; Buzyurov A. V; Gerasimov A. V; Gatiatulin A. K.; Ziganshin M. A.; Schick C.; Gorbatchuk V. V. New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry. // Cryst. Growth Des. — 2023. DOI: 10.1021/acs.cgd.3c00443	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=285563&p_lang=2	ru_RU
dc.description.abstract	CRYSTAL GROWTH & DESIGN	ru_RU
dc.description.abstract	Solid-state guest exchange is used as an efficient method to prepare very metastable polymorphs of indomethacin, including the polymorph observed earlier only in a mixture with a polymeric solvent and a new crystalline form of this drug with a negligibly small amount of the included solvent (guest). The used preparation procedure gives less stable inclusion compounds of indomethacin, which require a milder desolvation treatment than inclusion compounds formed in binary host−guest systems, so the metastable forms with a low first melting point can be prepared. For the characterization of indomethacin polymorphs, fast scanning calorimetry was used, along with conventional characterization methods. This method merges multistep polymorphic transitions, making the first melting point much more pronounced, so the different polymorphs become better discriminated.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	indomethacin	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	pseudopolymorphism	ru_RU
dc.subject	inclusion compound	ru_RU
dc.subject	fast scanning calorimetry	ru_RU
dc.title	New Polymorph of Indomethacin: Screening by Solid-State Guest Exchange and Characterization Using Fast Scanning Calorimetry	ru_RU
dc.type	Articles in international journals and collections	ru_RU