KFU. Card publication. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

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INCREASING SEVERITY OF SPINAL CORD INJURY RESULTS IN MICROGLIA/MACROPHAGES WITH ANNULAR-SHAPED MORPHOLOGY AND NO CHANGE IN EXPRESSION OF CD40 AND TUMOR GROWTH FACTOR-β DURING THE CHRONIC POST-INJURY STAGE

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Arkhipova Svetlana Sergeevna, author

Akhmetzyanova Elvira Ruslanovna, author

Kostennikov Aleksandr Aleksandrovich, author

Rizvanov Albert Anatolevich, author

Rogozhin Aleksandr Aleksandrovich, author

Sabirov Davran Khudayshukurovich, author

Timofeeva Anna Viktorovna, author

Other authors

Dzheyms Viktoriya , author

Authors, postgraduates KFU

Sabirov Davran Khudayshukurovich, postgraduate kfu

Bibliographic description in the original language

Akhmetzyanova, E.R., Timofeeva, A.V., Sabirov, D.K., Kostennikov, A.A., Rogozhin, A.A., James, V., Arkhipova, S.S., Rizvanov, A.A. and Mukhamedshina, Y.O., 2022. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage. Frontiers in molecular neuroscience, 14, p.802558.

Annotation

Frontiers in molecular neuroscience

Keywords

spinal cord injury, microglia, rat, polarization, morphology

The name of the journal

Frontiers in molecular neuroscience

URL

https://www.frontiersin.org/articles/10.3389/fnmol.2021.802558/full

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=284383&p_lang=2

Resource files

File name	Size (MB)	Format
F_fnmol_14_802558__4_.pdf	10,21	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Arkhipova Svetlana Sergeevna	ru_RU
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.contributor.author	Kostennikov Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Rogozhin Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Sabirov Davran Khudayshukurovich	ru_RU
dc.contributor.author	Timofeeva Anna Viktorovna	ru_RU
dc.contributor.author	Dzheyms Viktoriya	ru_RU
dc.contributor.author	Sabirov Davran Khudayshukurovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Akhmetzyanova, E.R., Timofeeva, A.V., Sabirov, D.K., Kostennikov, A.A., Rogozhin, A.A., James, V., Arkhipova, S.S., Rizvanov, A.A. and Mukhamedshina, Y.O., 2022. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage. Frontiers in molecular neuroscience, 14, p.802558.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=284383&p_lang=2	ru_RU
dc.description.abstract	Frontiers in molecular neuroscience	ru_RU
dc.description.abstract	Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as the severity of SCI increased. While we did not find significant quantitative changes in the populations of Iba1+/CD40+ and Iba1+/TGF-β+ microglia/macrophages with increased severity of SCI in the chronic period (60 dpi), we did determine changes in the expression of cytokines and mRNAs of genes-encoding microglial marker proteins, finding the greatest changes on days 7 and 14 after SCI between experimental groups with varying severity.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	microglia	ru_RU
dc.subject	rat	ru_RU
dc.subject	polarization	ru_RU
dc.subject	morphology	ru_RU
dc.title	Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage	ru_RU
dc.type	Articles in international journals and collections	ru_RU