KFU. Card publication. Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir

KAZAN
FEDERAL UNIVERSITY

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INFLUENCE OF HYDRATION AND THE SIZE OF THE MACROCYCLE OF NATIVE CYCLODEXTRINS ON THE SOLID PHASE INCLUSION OF RITONAVIR

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Gatiatulin Askar Kamilevich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Klimovickiy Aleksandr Evgenevich, author

Oselskaya Viktoriya Yurevna, author

Bibliographic description in the original language

Gatiatulin A. K. Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir [text] / A.K. Gatiatulin, V.Y. Oselskaya, A.E. Klimovitskii, M.A. Ziganshin, V.V. Gorbachuk // Journal of Structural Chemistry. — 2023. — V. 64(9). — P. 1702–1714.

Annotation

We study how the size of the macrocycle of native cyclodextrins and their hydration influence the inclusion of ritonavir under mechanical grinding conditions. A procedure is proposed to estimate the degree of inclusion of ritonavir by cyclodextrins using the crystallization of the unincluded guest in the grinding products at the water vapor treatment. Ritonavir is almost completely included by anhydrous α-, β-, and γ-cyclodextrins, resulting in the formation of inclusion compounds. The structure–property relationship between ritonavir inclusion in cyclodextrin hydrates and the size of the host macrocycle is nonlinear. Ritonavir is completely included by saturated β-cyclodextrin hydrate and intermediate γ-cyclodextrin hydrates. The degree of ritonavir inclusion by saturated hydrates of α-cyclodextrin and particularly of γ-cyclodextrin is small due to the competition of this guest with water.

Keywords

ritonavir, cyclodextrins, polymorphism, inclusion compound

The name of the journal

Journal of Structural Chemistry

URL

https://link.springer.com/article/10.1134/S0022476623090135#Bib1

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=284149&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gatiatulin Askar Kamilevich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Klimovickiy Aleksandr Evgenevich	ru_RU
dc.contributor.author	Oselskaya Viktoriya Yurevna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Gatiatulin A. K. Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir [text] / A.K. Gatiatulin, V.Y. Oselskaya, A.E. Klimovitskii, M.A. Ziganshin, V.V. Gorbachuk // Journal of Structural Chemistry. — 2023. — V. 64(9). — P. 1702–1714.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=284149&p_lang=2	ru_RU
dc.description.abstract	Journal of Structural Chemistry	ru_RU
dc.description.abstract	We study how the size of the macrocycle of native cyclodextrins and their hydration influence the inclusion of ritonavir under mechanical grinding conditions. A procedure is proposed to estimate the degree of inclusion of ritonavir by cyclodextrins using the crystallization of the unincluded guest in the grinding products at the water vapor treatment. Ritonavir is almost completely included by anhydrous α-, β-, and γ-cyclodextrins, resulting in the formation of inclusion compounds. The structure–property relationship between ritonavir inclusion in cyclodextrin hydrates and the size of the host macrocycle is nonlinear. Ritonavir is completely included by saturated β-cyclodextrin hydrate and intermediate γ-cyclodextrin hydrates. The degree of ritonavir inclusion by saturated hydrates of α-cyclodextrin and particularly of γ-cyclodextrin is small due to the competition of this guest with water.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ritonavir	ru_RU
dc.subject	cyclodextrins	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	inclusion compound	ru_RU
dc.title	Influence Of Hydration And The Size Of The Macrocycle Of Native Cyclodextrins On The Solid Phase Inclusion Of Ritonavir	ru_RU
dc.type	Articles in international journals and collections	ru_RU