KFU. Card publication. owards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines

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FEDERAL UNIVERSITY

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OWARDS ASYMMETRICAL METHYLENE BLUE ANALOGUES: SYNTHESIS AND REACTIVITY OF 3-N'-ARYLAMINOPHENOTHIAZINES

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Padnya Pavel Leonidovich, author

Khadieva Alyona Igorevna, author

Shibaeva Kseniya Sergeevna, author

Other authors

Piskunov Aleksandr , author

Authors, students KFU

Rayanov Mansur Ramilevich, author

Bibliographic description in the original language

Khadieva A. Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines / A. Khadieva, M. Rayanov, K. Shibaeva, A. Piskunov, P. Padnya, I. Stoikov // Molecules. – 2022. – V. 27. – �. 9. – P. 3024.

Annotation

The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 -arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-N0 -arylaminophenothiazine derivative. The obtained experimental data are confirmed by DFT studies. Two synthetic routes for asymmetrical phenothiazine diary lamino derivatives were suggested and verified. The developed convenient and versatile synthetic approach makes it easy to obtain aromatic Methylene Blue isostructural analogues with various substituents. As a result, a series of novel 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 - arylamino)phenothiazines containing ester, tert-butoxycarbonyl, sulfonic acid, hydroxyl and amine groups were obtained in high yields.

Keywords

Methylene Blue; phenothiazine; synthesis; reactivity; DFT

The name of the journal

Molecules

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=283526&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Padnya Pavel Leonidovich	ru_RU
dc.contributor.author	Khadieva Alyona Igorevna	ru_RU
dc.contributor.author	Shibaeva Kseniya Sergeevna	ru_RU
dc.contributor.author	Piskunov Aleksandr	ru_RU
dc.contributor.author	Rayanov Mansur Ramilevich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Khadieva A. Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines / A. Khadieva, M. Rayanov, K. Shibaeva, A. Piskunov, P. Padnya, I. Stoikov // Molecules. – 2022. – V. 27. – �. 9. – P. 3024.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=283526&p_lang=2	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 -arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-N0 -arylaminophenothiazine derivative. The obtained experimental data are confirmed by DFT studies. Two synthetic routes for asymmetrical phenothiazine diary lamino derivatives were suggested and verified. The developed convenient and versatile synthetic approach makes it easy to obtain aromatic Methylene Blue isostructural analogues with various substituents. As a result, a series of novel 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 - arylamino)phenothiazines containing ester, tert-butoxycarbonyl, sulfonic acid, hydroxyl and amine groups were obtained in high yields.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	owards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines	ru_RU
dc.type	Articles in international journals and collections	ru_RU