KFU. Card publication. Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease

KAZAN
FEDERAL UNIVERSITY

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FAECAL NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN AS A NON INVASIVE BIOMARKER IN INFLAMMATORY BOWEL DISEASE

Form of presentation

Articles in international journals and collections

Year of publication

2022

Authors, employees of KFU

Blatt Nataliya Lvovna, author

Other authors

Abdulganieva Diana Ildarovna, Mukhametova Dilyara Damirovna, Valeeva Ildariya Khayrullovna, Zinkevich Oleg Danilovich, Safina Nellya Akhmetovna, Odincova Alfiya Kharisovna

Authors, postgraduates KFU

Korovina Marina Olegovna, postgraduate kfu

Bibliographic description in the original language

Abdulganieva D.I., Mukhametova D.D., Valeeva I. K, Blatt N., Zinkevich?O.D., Safina N.A., Odintsova A. Kh., Korovina M.O. Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease // BioNanoScience (2022). 12:1381?1387 https://doi.org/10.1007/s12668-022-00999-7

Annotation

The aim was to evaluate NGAL level in faeces in patients with IBD. We included 107 patients with IBD ? 96 cases of IBD flare up (66 ? UC and 29 ? CD), 11 patients in IBD remission (6 ? UC and 6 ? CD) and 30 healthy controls. There was a confirmed faecal NGAL level in all patients. Faecal NGAL was significantly higher in active IBD ? 4122 [861; 6850] ng/ml comparing with healthy persons ? 181 [169; 720] ng/ml (p < 0,001) or inactive IBD ? 1136 [116; 3004] ng/ml (p < 0,05). In active UC (4668 [1298; 7792] ng/ml), it was higher than in active CD (2688 [200; 5710] ng/ml) (p < 0.05). We found that faecal NGAL as a marker has sensitivity of 72.9%, specificity of 93.3% and AUC of 0.88 for distinguishing IBD from healthies. Sensitivity, specificity and AUC were 72.9%, 45.5% and 0.72, respectively, for distinguishing exacerbation from remission of disease. Faecal NGAL is a new promising marker for diagnosis active IBD, which has high sensitivity, specificity and AUC.

Keywords

Infammatory bowel disease, Crohn?s disease, Ulcerative colitis, Lipocalin-2 ,Neutrophil gelatinase-associated lipocalin, NGAL

The name of the journal

BioNanoScience

Publishing house

Springer

URL

https://link.springer.com/article/10.1007/s12668-022-00999-7

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=281652&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Blatt Nataliya Lvovna	ru_RU
dc.contributor.author	Korovina Marina Olegovna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Abdulganieva D.I., Mukhametova D.D., Valeeva I. K, Blatt N., Zinkevich?O.D., Safina N.A., Odintsova A. Kh., Korovina M.O. Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease // BioNanoScienc� (2022). 12:1381?1387 https://doi.org/10.1007/s12668-022-00999-7	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=281652&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The aim was to evaluate NGAL level in faeces in patients with IBD. We included 107 patients with IBD ? 96 cases of IBD flare up (66 ? UC and 29 ? CD), 11 patients in IBD remission (6 ? UC and 6 ? CD) and 30 healthy controls. There was a confirmed faecal NGAL level in all patients. Faecal NGAL was significantly higher in active IBD ? 4122 [861; 6850] ng/ml comparing with healthy persons ? 181 [169; 720] ng/ml (p < 0,001) or inactive IBD ? 1136 [116; 3004] ng/ml (p < 0,05). In active UC (4668 [1298; 7792] ng/ml), it was higher than in active CD (2688 [200; 5710] ng/ml) (p < 0.05). We found that faecal NGAL as a marker has sensitivity of 72.9%, specificity of 93.3% and AUC of 0.88 for distinguishing IBD from healthies. Sensitivity, specificity and AUC were 72.9%, 45.5% and 0.72, respectively, for distinguishing exacerbation from remission of disease. Faecal NGAL is a new promising marker for diagnosis active IBD, which has high sensitivity, specificity and AUC.	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	Springer	ru_RU
dc.subject	Infammatory bowel disease	ru_RU
dc.subject	Crohn?s disease	ru_RU
dc.subject	Ulcerative colitis	ru_RU
dc.subject	Lipocalin-2	ru_RU
dc.subject	Neutrophil gelatinase-associated lipocalin	ru_RU
dc.subject	NGAL	ru_RU
dc.title	Faecal Neutrophil Gelatinase associated Lipocalin as a Non invasive Biomarker in Inflammatory Bowel Disease	ru_RU
dc.type	Articles in international journals and collections	ru_RU