KFU. Card publication. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer

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MORPHOFUNCTIONAL CHANGES IN THE SPINAL CORD OF RATS AFTER CONTUSION INJURY WITH LOCAL DELIVERY OF METHYLPREDNISOLONE IN COMBINATION WITH A COPOLYMER

Form of presentation

Articles in international journals and collections

Year of publication

2023

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Authors, employees of KFU

Sabirova Diana Emilevna, author

Sachenkov Oskar Aleksandrovich, author

Chernova Olga Nikolaevna, author

Authors, postgraduates KFU

Sabirova Diana Emilevna, postgraduate kfu

Bibliographic description in the original language

Baltin, M.E. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer/M.E. Baltin, D.E.Sabirova, O.N.Chernova, T. V. Baltina, O. A. Sachenkov //Bull Exp Biol Med. - 2023. - Vol.174. - P. 810–815.

Annotation

We studied the neuroprotective effect of local application of methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the sensorimotor functions in rats.

Keywords

spinal cord injury, methylprednisolone, trifunctional block copolymer, morphometric analysis, evoked muscle responses

The name of the journal

B EXP BIOL MED+

URL

https://link.springer.com/article/10.1007/s10517-023-05795-1

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=280693&p_lang=2

Resource files

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F_Byulleten2023.pdf	0,11	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Sabirova Diana Emilevna	ru_RU
dc.contributor.author	Sachenkov Oskar Aleksandrovich	ru_RU
dc.contributor.author	Chernova Olga Nikolaevna	ru_RU
dc.contributor.author	Sabirova Diana Emilevna	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Baltin, M.E. Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer/M.E. Baltin, D.E.Sabirova, O.N.Chernova, T. V. Baltina, O. A. Sachenkov //Bull Exp Biol Med. - 2023. - Vol.174. - P. 810–815.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=280693&p_lang=2	ru_RU
dc.description.abstract	B EXP BIOL MED+	ru_RU
dc.description.abstract	We studied the neuroprotective effect of local application of methylprednisolone in combination with a block copolymer after contusion spinal cord injury in rats. Histological analysis of the spinal cord showed that delivery of a complex of methylprednisolone with a block copolymer reduced the volume of white and gray matter lesions. An increase in the amplitude of the evoked response of the gastrocnemius muscle was observed during epidural stimulation of the spinal cord 6 h after the injury. The maximum amplitude of the muscle response was greater in the group with local delivery of the methylprednisolone complex with the polymer 72 h after the injury. The obtained results demonstrate the neuroprotective effect of the local administration of the complex and allow to make positive prognosis for the recovery of the sensorimotor functions in rats.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	methylprednisolone	ru_RU
dc.subject	trifunctional block copolymer	ru_RU
dc.subject	morphometric analysis	ru_RU
dc.subject	evoked muscle responses	ru_RU
dc.title	Morphofunctional Changes in the Spinal Cord of Rats after Contusion Injury with Local Delivery of Methylprednisolone in Combination with a Copolymer	ru_RU
dc.type	Articles in international journals and collections	ru_RU