KFU. Card publication. Membrane Microvesicles as Potential Vaccine Candidates

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

MEMBRANE MICROVESICLES AS POTENTIAL VACCINE CANDIDATES

Form of presentation

International monographs

Year of publication

2021

Язык

английский

Authors, employees of KFU

Garanina Ekaterina Evgenevna, author

Khaybullina Svetlana Francevna, author

Shkayr Layali , author

Bibliographic description in the original language

Shkair L, Garanina EE, Stott RJ, Foster TL, Rizvanov AA, Khaiboullina SF. Membrane Microvesicles as Potential Vaccine Candidates. International Journal of Molecular Sciences. 2021; 22(3):1142. https://doi.org/10.3390/ijms22031142

Annotation

The prevention and control of infectious diseases is crucial to the maintenance and protection of social and public healthcare. The global impact of SARS-CoV-2 has demonstrated how outbreaks of emerging and re-emerging infections can lead to pandemics of significant public health and socio-economic burden. Vaccination is one of the most effective approaches to protect against infectious diseases, and to date, multiple vaccines have been successfully used to protect against and eradicate both viral and bacterial pathogens. The main criterion of vaccine efficacy is the induction of specific humoral and cellular immune responses, and it is well established that immunogenicity depends on the type of vaccine as well as the route of delivery. In addition, antigen delivery to immune organs and the site of injection can potentiate efficacy of the vaccine. In light of this, microvesicles have been suggested as potential vehicles for antigen delivery as they can carry various immunogenic molecules including proteins, nucleic acids and polysaccharides directly to target cells. In this review, we focus on the mechanisms of microvesicle biogenesis and the role of microvesicles in infectious diseases. Further, we discuss the application of microvesicles as a novel and effective vaccine delivery system.

Keywords

vaccine; microvesicles; delivery system; infectious diseases; immunity

URL

https://www.mdpi.com/972276

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=274007&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.contributor.author	Shkayr Layali	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Shkair L, Garanina EE, Stott RJ, Foster TL, Rizvanov AA, Khaiboullina SF. Membrane Microvesicles as Potential Vaccine Candidates. International Journal of Molecular Sciences. 2021; 22(3):1142. https://doi.org/10.3390/ijms22031142	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=274007&p_lang=2	ru_RU
dc.description.abstract	The prevention and control of infectious diseases is crucial to the maintenance and protection of social and public healthcare. The global impact of SARS-CoV-2 has demonstrated how outbreaks of emerging and re-emerging infections can lead to pandemics of significant public health and socio-economic burden. Vaccination is one of the most effective approaches to protect against infectious diseases, and to date, multiple vaccines have been successfully used to protect against and eradicate both viral and bacterial pathogens. The main criterion of vaccine efficacy is the induction of specific humoral and cellular immune responses, and it is well established that immunogenicity depends on the type of vaccine as well as the route of delivery. In addition, antigen delivery to immune organs and the site of injection can potentiate efficacy of the vaccine. In light of this, microvesicles have been suggested as potential vehicles for antigen delivery as they can carry various immunogenic molecules including proteins, nucleic acids and polysaccharides directly to target cells. In this review, we focus on the mechanisms of microvesicle biogenesis and the role of microvesicles in infectious diseases. Further, we discuss the application of microvesicles as a novel and effective vaccine delivery system.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Membrane Microvesicles as Potential Vaccine Candidates	ru_RU
dc.type	International monographs	ru_RU