KFU. Card publication. Transition metal-doped cryogels as bioactive materials for wound healing applications

KAZAN
FEDERAL UNIVERSITY

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TRANSITION METAL-DOPED CRYOGELS AS BIOACTIVE MATERIALS FOR WOUND HEALING APPLICATIONS

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Zukhayb Mokhamed , author

Bibliographic description in the original language

Duong Luong, Abdulla A Yergeshov, Mohamed Zoughaib, Farida R Sadykova, Bulat I Gareev, Irina N Savina, Timur I Abdullin. Transition metal-doped cryogels as bioactive materials for wound healing applications // Materials Science and Engineering: C. - 2019. - V.103. - P. 109759

Annotation

Transition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble divalent TM, such as Zn, Cu, Mn and Co, were stably incorporated into gelatin network during cryogelation. TM content in the resultant cryogels varied from 0.1 × 103 to 11.8 × 103 ppm, depending on the TM type and concentration in the reaction solution. Zn component was uniformly complexed with the gelatin scaffold according to elemental imaging, increasing the swelling of polymer walls and the G'/G« values and also decreasing the size of cryogel macro-pores. Zn-doped cryogels supported migration of human skin fibroblasts (HSF); only upper Zn content of 11.8 × 103 ppm in the scaffold caused c.a. 50% inhibition of cell growth. Zn ions solubilized in culture medium were more active towards HSF (IC50 ≈ 0.3 mM). Treatment of splinted full-skin excisional wounds in rats with the Zn-doped and non-doped cryogels showed that Zn considerably promoted passing inflammatory/proliferation phases of healing process, inducing more intense dermis formation and structuration. The results show the feasibility of development of cryogel based formulations with different TM and support high phase-specific ability of the Zn-gelatin cryogels to repair acute wounds.

Keywords

Transition metalsBiomaterialsCryogelsGelatinZincExcisional wound modelWound healing

The name of the journal

Materials Science and Engineering C

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=273461&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zukhayb Mokhamed	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Duong Luong, Abdulla A Yergeshov, Mohamed Zoughaib, Farida R Sadykova, Bulat I Gareev, Irina N Savina, Timur I Abdullin. Transition metal-doped cryogels as bioactive materials for wound healing applications // Materials Science and Engineering: C. - 2019. - V.103. - P. 109759	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=273461&p_lang=2	ru_RU
dc.description.abstract	Materials Science and Engineering C	ru_RU
dc.description.abstract	Transition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble divalent TM, such as Zn, Cu, Mn and Co, were stably incorporated into gelatin network during cryogelation. TM content in the resultant cryogels varied from 0.1 × 103 to 11.8 × 103 ppm, depending on the TM type and concentration in the reaction solution. Zn component was uniformly complexed with the gelatin scaffold according to elemental imaging, increasing the swelling of polymer walls and the G'/G« values and also decreasing the size of cryogel macro-pores. Zn-doped cryogels supported migration of human skin fibroblasts (HSF); only upper Zn content of 11.8 × 103 ppm in the scaffold caused c.a. 50% inhibition of cell growth. Zn ions solubilized in culture medium were more active towards HSF (IC50 ≈ 0.3 mM). Treatment of splinted full-skin excisional wounds in rats with the Zn-doped and non-doped cryogels showed that Zn considerably promoted passing inflammatory/proliferation phases of healing process, inducing more intense dermis formation and structuration. The results show the feasibility of development of cryogel based formulations with different TM and support high phase-specific ability of the Zn-gelatin cryogels to repair acute wounds.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Transition metal-doped cryogels as bioactive materials for wound healing applications	ru_RU
dc.type	Articles in international journals and collections	ru_RU