KFU. Card publication. Role of the catalytic activity of dna-antibodies in the diagnosis and monitoring of the progression of different clinical forms of cardiovascular disease

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ROLE OF THE CATALYTIC ACTIVITY OF DNA-ANTIBODIES IN THE DIAGNOSIS AND MONITORING OF THE PROGRESSION OF DIFFERENT CLINICAL FORMS OF CARDIOVASCULAR DISEASE

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Abramov Sergey Nikolaevich, author

Abramova Zinaida Ivanovna, author

Ganeeva Liliya Akhatovna, author

Skibo Yuliya Valerevna, author

Other authors

LEGBA BORIS B. , author

Voodunon Sirill , author

Bibliographic description in the original language

Ganeeva I. A. Role of the catalytic activity of dna-antibodies in the diagnosis and monitoring of the progression of different clinical forms of cardiovascular disease/I. A. Ganeeva, C. A. Vodounon, S. N. Abramov, B. B. Legba, H. R.I. Mamadou, Y. V. Skibo , Z. I. Abramova// The Journal of Biochemistry.-2022 (ID is JB-22-08-0283 na recenzirovanii, IF-3.241, Q2)

Annotation

Coronary heart disease is a major health problem worldwide. One of the current challenges related to its prevention is that of early diagnosis. This study focuses on the search for predictive immunological biomarkers for the diagnosis and control of the evolution of different clinical forms of cardiovascular diseases. Anti-DNA antibodies were searched in the blood serum of 57 patients with cardiovascular disease of various forms and 27 relatively healthy donors who gave their consent. The determination of the level of anti-DNA antibodies was carried out by enzyme immunoassay. The catalytic activity of the anti-DNA antibody was estimated by the agarose gel electrophoresis method. The results showed a significant increase in the levels of anti-nDNA Ac and anti-dDNA Ac between groups of patients with cardiovascular disease. A high anti-nDNA Ac level was observed in 70.70% of patients with cardiovascular diseases. The anti-DNA antibodies found in the serum of the different groups exhibit catalytic activities and are able to transform the super-coiled DNA into linear and circular DNA. From these data, it appears that anti-DNA autoantibodies play a preponderant role in the pathogenesis of cardiovascular diseases and could be used as a biomarker in the diagnosis of this disease

Keywords

anti-DNA antibodies, catalytic activities, cardiovascular diseases, biomarker, diagnosis

The name of the journal

The Journal of Biochemistry

URL

https://cloud.mail.ru/attaches/101c9E372C7fb56986238Bd3Bf6Ff095%3BgD9cZSB1tT1tddyW

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=272643&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramov Sergey Nikolaevich	ru_RU
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Ganeeva Liliya Akhatovna	ru_RU
dc.contributor.author	Skibo Yuliya Valerevna	ru_RU
dc.contributor.author	LEGBA BORIS B.	ru_RU
dc.contributor.author	Voodunon Sirill	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Ganeeva I. A. Role of the catalytic activity of dna-antibodies in the diagnosis and monitoring of the progression of different clinical forms of cardiovascular disease/I. A. Ganeeva, C. A. Vodounon, S. N. Abramov, B. B. Legba, H. R.I. Mamadou, Y. V. Skibo , Z. I. Abramova// The Journal of Biochemistry.-2022 (ID is JB-22-08-0283 �� , IF-3.241, Q2)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=272643&p_lang=2	ru_RU
dc.description.abstract	The Journal of Biochemistry	ru_RU
dc.description.abstract	Coronary heart disease is a major health problem worldwide. One of the current challenges related to its prevention is that of early diagnosis. This study focuses on the search for predictive immunological biomarkers for the diagnosis and control of the evolution of different clinical forms of cardiovascular diseases. Anti-DNA antibodies were searched in the blood serum of 57 patients with cardiovascular disease of various forms and 27 relatively healthy donors who gave their consent. The determination of the level of anti-DNA antibodies was carried out by enzyme immunoassay. The catalytic activity of the anti-DNA antibody was estimated by the agarose gel electrophoresis method. The results showed a significant increase in the levels of anti-nDNA Ac and anti-dDNA Ac between groups of patients with cardiovascular disease. A high anti-nDNA Ac level was observed in 70.70% of patients with cardiovascular diseases. The anti-DNA antibodies found in the serum of the different groups exhibit catalytic activities and are able to transform the super-coiled DNA into linear and circular DNA. From these data, it appears that anti-DNA autoantibodies play a preponderant role in the pathogenesis of cardiovascular diseases and could be used as a biomarker in the diagnosis of this disease	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	anti-DNA antibodies	ru_RU
dc.subject	catalytic activities	ru_RU
dc.subject	cardiovascular diseases	ru_RU
dc.subject	biomarker	ru_RU
dc.subject	diagnosis	ru_RU
dc.title	Role of the catalytic activity of dna-antibodies in the diagnosis and monitoring of the progression of different clinical forms of cardiovascular disease	ru_RU
dc.type	Articles in international journals and collections	ru_RU