KFU. Card publication. Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ)

KAZAN
FEDERAL UNIVERSITY

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ЭКСПРЕССИЯ ПОДДЕРЖИВАЮЩЕГО БЕЛКА NEDD9 КАК НЕГАТИВНЫЙ ПРОГНОСТИЧЕСКИЙ МАРКЕР ПРИ НЕМЕЛКОКЛЕТОЧНОМ РАКЕ ЛЕГКОГО (НМРЛ)

Form of presentation

Articles in Russian journals and collections

Year of publication

2022

Язык

русский

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Bibliographic description in the original language

Tikhomirova M.V. Ekspressiya podderzhivayushhego belka NEDD9 kak negativnyy prognosticheskiy marker pri nemelkokletochnom rake legkogo (NMRL) / M.V. Tikhomirova, V.V. Barmin, Yu.A. Topchu, A.M. Mazitova, E.Yu. Ratner, A.A. Sabirov, Z.I. Abramova, A.Ya. Deneka // Sibirskiy onkologicheskiy zhurnal. – 2022. – T. 21. – №4. – S.47–55

Annotation

The purpose of the study was to assess the prognostic significance of a scaffolding NEDD9 protein in patients with non-small cell lung cancer (NSCLC). NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as PI3K-AKT-mTOR, Ras-ERK, which play key roles in tumor progression. several studies define the regulatory role of NEDD9 in progression of several solid cancers, including non-small cell lung cancer (NSCLC), however its role as a prediction biomarker is minimally assessed. Materials and methods. In the current study quantitative immunohistochemical (IHC) approach was utilized to characterize NEDD9 expression in a cohort of NSCLC primary tumor samples (n=16), and correlative statistical analysis was performed between NEDD9 expression and a set of patients' clinical and pathological characteristics. Results of the IHC analysis were validated using broader TCGA RNAseq dataset (n=566). Results. The study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages II and IV (p<0.05). Next, NEDD9 expression level was approximated to high and low (based on median h-score=56.14) and statistical survival analysis revealed a positive correlative trend between the decreased expression of NEDD9 and the decrease in the overall (OS) and progression-free survival (PFS) of the patients. Analysis of TCGA dataset harboring RNA seq data confirmed statistically significant correlation (p=0.05) between low NEDD9 expression and decreased OS. Conclusion. This study suggests that the expression of the scaffolding protein NEDD9, both at the protein and RNA levels, positively correlates with a negative prognosis in NSCLC, suggesting that it can potentially be used as a novel biomarker of disease progression. Further basic and clinical research defining the role of NEDD9 in the progression and metastasis of NSCLC are strongly warranted.

Keywords

немелкоклеточный рак легкого, общая выживаемость, беспрогрессивная выживаемость, поддерживающие белки, NEDD9, маркеры-предикторы

The name of the journal

СИБИРСКИЙ ОНКОЛОГИЧЕСКИЙ ЖУРНАЛ

URL

https://www.siboncoj.ru/jour/article/view/2242

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=271793&p_lang=2

Resource files

File name	Size (MB)	Format
F_NEDD9_kak_negativnyj_prognosticheskij_marker_pri_NMRL.pdf	1,97	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Тихомирова М.В. Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ) / М.В. Тихомирова, В.В. Бармин, Ю.А. Топчу, А.М. Мазитова, Е.Ю. Ратнер, А.А. Сабиров, З.И. Абрамова, А.Я. Денека // Сибирский онкологический журнал. – 2022. – Т. 21. – №4. – С.47–55	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=271793&p_lang=2	ru_RU
dc.description.abstract	СИБИРСКИЙ ОНКОЛОГИЧЕСКИЙ ЖУРНАЛ	ru_RU
dc.description.abstract	The purpose of the study was to assess the prognostic significance of a scaffolding NEDD9 protein in patients with non-small cell lung cancer (NSCLC). NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as PI3K-AKT-mTOR, Ras-ERK, which play key roles in tumor progression. several studies define the regulatory role of NEDD9 in progression of several solid cancers, including non-small cell lung cancer (NSCLC), however its role as a prediction biomarker is minimally assessed. Materials and methods. In the current study quantitative immunohistochemical (IHC) approach was utilized to characterize NEDD9 expression in a cohort of NSCLC primary tumor samples (n=16), and correlative statistical analysis was performed between NEDD9 expression and a set of patients' clinical and pathological characteristics. Results of the IHC analysis were validated using broader TCGA RNAseq dataset (n=566). Results. The study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages II and IV (p<0.05). Next, NEDD9 expression level was approximated to high and low (based on median h-score=56.14) and statistical survival analysis revealed a positive correlative trend between the decreased expression of NEDD9 and the decrease in the overall (OS) and progression-free survival (PFS) of the patients. Analysis of TCGA dataset harboring RNA seq data confirmed statistically significant correlation (p=0.05) between low NEDD9 expression and decreased OS. Conclusion. This study suggests that the expression of the scaffolding protein NEDD9, both at the protein and RNA levels, positively correlates with a negative prognosis in NSCLC, suggesting that it can potentially be used as a novel biomarker of disease progression. Further basic and clinical research defining the role of NEDD9 in the progression and metastasis of NSCLC are strongly warranted.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	немелкоклеточный рак легкого	ru_RU
dc.subject	общая выживаемость	ru_RU
dc.subject	беспрогрессивная выживаемость	ru_RU
dc.subject	поддерживающие белки	ru_RU
dc.subject	NEDD9	ru_RU
dc.subject	маркеры-предикторы	ru_RU
dc.title	Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ)	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU