KFU. Card publication. Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis.

KAZAN
FEDERAL UNIVERSITY

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SEASONAL CHANGES IN SERUM METABOLITE AND CYTOKINE LEVELS IN MULTIPLE SCLEROSIS.

Form of presentation

Conference proceedings in Russian journals and collections

Year of publication

2022

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Authors, employees of KFU

Laykov Aleksandr Vladimirovich, author

Lezhnyova Vera Runarovna, author

Lopukhov Leonid Valentinovich, author

Markelova Mariya Ivanovna, author

Martynova Ekaterina Vladimirovna, author

Salafutdinov Ilnur Ildusovich, author

Khaybullina Svetlana Francevna, author

Bibliographic description in the original language

Lezhniova V.R., Martynova E.V., Khaibullin T.I., Salafutdinov I.I., Markelova M.I., Laikov A.V., Lopukhov L.V., & Khaibullina S.F. (2022). Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis. Fundamental and applied research for key propriety areas of bioecology and biotechnology, 213-220. Cheboksary: PH «Sreda«. doi:10.31483/r-102302

Annotation

All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»

Keywords

multiple sclerosis, metabolites, season exacerbation, pathogenesis

The name of the journal

All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»

URL

https://phsreda.com/en/article/102302/discussion_platform

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=268293&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Laykov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Lezhnyova Vera Runarovna	ru_RU
dc.contributor.author	Lopukhov Leonid Valentinovich	ru_RU
dc.contributor.author	Markelova Mariya Ivanovna	ru_RU
dc.contributor.author	Martynova Ekaterina Vladimirovna	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Lezhniova V.R., Martynova E.V., Khaibullin T.I., Salafutdinov I.I., Markelova M.I., Laikov A.V., Lopukhov L.V., & Khaibullina S.F. (2022). Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis. Fundamental and applied research for key propriety areas of bioecology and biotechnology, 213-220. ��: PH «Sreda«. doi:10.31483/r-102302	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=268293&p_lang=2	ru_RU
dc.description.abstract	All-Russian scientific conference with International Participation «Fundamental and applied research for key propriety areas of bioecology and biotechnology»	ru_RU
dc.description.abstract	Multiple sclerosis (MS) is a chronic debilitating disease of unknown etiology. The disease has a seasonal exacerbation of clinical symptoms, which are frequently described in spring and summer. However, the mechanisms of such seasonal exacerbations remain unknown. In this study, we used targeted metabolomics analysis of serum samples using LC-MC/MC to determine seasonal changes in metabolites. We have found changes in multiple metabolites which differed depending on season. The ceramides, belonging to the sphingolipid pathway, were found activated in spring-summer (SS) and fall-winter (FW) MS, suggesting their central role in disease pathogenesis. Our identification of ceramide activation suggests a mechanism of neuron damage in MS which could be further investigated as therapeutic targets.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	multiple sclerosis	ru_RU
dc.subject	metabolites	ru_RU
dc.subject	season exacerbation	ru_RU
dc.subject	pathogenesis	ru_RU
dc.title	Seasonal changes in serum metabolite and cytokine levels in Multiple Sclerosis.	ru_RU
dc.type	Conference proceedings in Russian journals and collections	ru_RU