KFU. Card publication. Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats

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HYPERHOMOCYSTEINEMIA INCREASES CORTICAL EXCITABILITY AND AGGRAVATES MECHANICAL HYPERALGESIA AND ANXIETY IN A NITROGLYCERINE-INDUCED MIGRAINE MODEL IN RATS

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Bogatova Kseniya Sergeevna, author

Gerasimova Elena Vyacheslavovna, author

Giniatullin Rashid Askhatovich, author

Yakovleva Olga Vladislavovna, author

Authors, students KFU

Enikeev Daniel Ruslanovich, author

Bibliographic description in the original language

Gerasimova, E. Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats / Gerasimova, E., Yakovleva, O., Enikeev, D., Bogatova, K, Hermann A, Giniatullin, R., Sitdikova, G.// Biomolecules, 2022, 12(5), 735

Annotation

Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at high concentrations. Population studies suggest an association between plasma homocysteine levels and the risk of migraine headaches. The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin. Animals with hHCY were characterized by migraine-related symptoms such as mechanical hyperalgesia, high-level anxiety, photophobia, as well as an enhanced level of neuronal activity in the somatosensory cortex along with a lower threshold of CSD generation. Likewise, acute or chronic intermittent administration of nitroglycerin also induced the development of mechanical allodynia, photophobia and anxiety in control groups. However, these symptoms were more pronounced in rats with hHCY. Unlike hHCY, nitroglycerin administration did not affect the threshold of CSD generation, but like hHCY, increased the background neuronal activity in layers 2/3 and 4 of the cerebral cortex. The latter was more pronounced in animals with hHCY. Thus, the migraine profile associated with hHCY can be further exaggerated in conditions with enhanced levels of migraine triggering the gaseous transmitter NO. Our data are consistent with the view that high levels of plasma homocysteine can act as a risk factor for the development of migraine.

Keywords

allodynia; anxiety; cortical excitability; cortical spreading depression; hyperhomocysteinemia; migraine; nitroglycerine; photophobia

The name of the journal

BIOMOLECULES

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=266796&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogatova Kseniya Sergeevna	ru_RU
dc.contributor.author	Gerasimova Elena Vyacheslavovna	ru_RU
dc.contributor.author	Giniatullin Rashid Askhatovich	ru_RU
dc.contributor.author	Yakovleva Olga Vladislavovna	ru_RU
dc.contributor.author	Enikeev Daniel Ruslanovich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Gerasimova, E. Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats / Gerasimova, E., Yakovleva, O., Enikeev, D., Bogatova, K, Hermann A, Giniatullin, R., Sitdikova, G.// Biomolecules, 2022, 12(5), 735	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=266796&p_lang=2	ru_RU
dc.description.abstract	BIOMOLECULES	ru_RU
dc.description.abstract	Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at high concentrations. Population studies suggest an association between plasma homocysteine levels and the risk of migraine headaches. The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin. Animals with hHCY were characterized by migraine-related symptoms such as mechanical hyperalgesia, high-level anxiety, photophobia, as well as an enhanced level of neuronal activity in the somatosensory cortex along with a lower threshold of CSD generation. Likewise, acute or chronic intermittent administration of nitroglycerin also induced the development of mechanical allodynia, photophobia and anxiety in control groups. However, these symptoms were more pronounced in rats with hHCY. Unlike hHCY, nitroglycerin administration did not affect the threshold of CSD generation, but like hHCY, increased the background neuronal activity in layers 2/3 and 4 of the cerebral cortex. The latter was more pronounced in animals with hHCY. Thus, the migraine profile associated with hHCY can be further exaggerated in conditions with enhanced levels of migraine triggering the gaseous transmitter NO. Our data are consistent with the view that high levels of plasma homocysteine can act as a risk factor for the development of migraine.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats	ru_RU
dc.type	Articles in international journals and collections	ru_RU