KFU. Card publication. Association of gene polymorphisms with body weight changes in prediabetic patients

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ASSOCIATION OF GENE POLYMORPHISMS WITH BODY WEIGHT CHANGES IN PREDIABETIC PATIENTS

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Valeeva Elena Valerevna, author

Other authors

Ahmetov Ildus Ilyasovich, author

Egorova Emiliya Sergeevna, author

Khasanova Kamilya , author

Kiseleva Tatyana Aleksandrovna, author

Medvedeva Mariya , author

Pickering Craig , author

Valeeva Farida Vadutovna, author

Bibliographic description in the original language

Valeeva F.V., Medvedeva M.S., Khasanova K.B., Valeeva E.V., Kiseleva T.A., Egorova E.S., Pickering C., Ahmetov I.I. Association of gene polymorphisms with body weight changes in prediabetic patients // Molecular biology reports. 2022.

Annotation

Molecular biology reports

Keywords

Diet; Obesity; Risk allele; Single nucleotide polymorphism; Type 2 diabetes.

The name of the journal

Molecular biology reports

URL

https://link.springer.com/article/10.1007/s11033-022-07254-y

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=266752&p_lang=2

Resource files

File name	Size (MB)	Format
Valeeva2022_Article_AssociationOfGenePolymorphisms.pdf	0,66	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Valeeva Elena Valerevna	ru_RU
dc.contributor.author	Ahmetov Ildus Ilyasovich	ru_RU
dc.contributor.author	Egorova Emiliya Sergeevna	ru_RU
dc.contributor.author	Khasanova Kamilya	ru_RU
dc.contributor.author	Kiseleva Tatyana Aleksandrovna	ru_RU
dc.contributor.author	Medvedeva Mariya	ru_RU
dc.contributor.author	Pickering Craig	ru_RU
dc.contributor.author	Valeeva Farida Vadutovna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Valeeva F.V., Medvedeva M.S., Khasanova K.B., Valeeva E.V., Kiseleva T.A., Egorova E.S., Pickering C., Ahmetov I.I. Association of gene polymorphisms with body weight changes in prediabetic patients // Molecular biology reports. 2022.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=266752&p_lang=2	ru_RU
dc.description.abstract	Molecular biology reports	ru_RU
dc.description.abstract	Background: Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146. Knowledge of the association between these single nucleotide polymorphisms (SNPs) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, and TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders. Methods and results: From 327 patients, a subgroup of 81 prediabetic female patients (48.7 ? 14.8 years) of Eastern European descent participated in a 3-month study comprised of diet therapy or diet therapy accompanied with metformin treatment. Bioelectrical impedance analysis and genotyping of MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146 polymorphisms were performed. The MC4R CC and TCF7L2 TT genotypes were associated with increased risk of T2D (OR = 1.46, p = 0.05 and OR = 2.47, p = 0.006, respectively). PPARG CC homozygotes experienced increased weight loss; however, no additional improvements were experienced with the addition of metformin. MC4R TT homozygotes who took metformin alongside dietary intervention experienced increased weight loss and reductions in fat mass (p < 0.05). Conclusions: We have shown that the obesity-protective alleles (MC4R T and PPARG C) were positively associated with weight loss efficiency. Furthermore, we confirmed the previous association of the MC4R C and TCF7L2 T alleles with T2D risk.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Association of gene polymorphisms with body weight changes in prediabetic patients	ru_RU
dc.type	Articles in international journals and collections	ru_RU