KFU. Card publication. Supramolecular assembly of calix[4]resorcinarenes and chitosan for the design of drug nanocontainers with selective effects on diseased cells

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SUPRAMOLECULAR ASSEMBLY OF CALIX[4]RESORCINARENES AND CHITOSAN FOR THE DESIGN OF DRUG NANOCONTAINERS WITH SELECTIVE EFFECTS ON DISEASED CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Kashapov R. Supramolecular assembly of calix[4]resorcinarenes and chitosan for the design of drug nanocontainers with selective effects on diseased cells / R. Kashapov, Yu. Razuvayeva, A. Ziganshina, T. Sergeeva, N. Kashapova, A. Sapunova, A. Voloshina, I. Nizameev, V. Salnikov, L. Zakharova // New J. Chem. – 2020. – 44. – 17854-17863.

Annotation

In this paper, the spontaneous formation of nanoparticles through supramolecular interactions between chitosan and sulfonated calix[4]resorcinarenes was demonstrated. A set of physical–chemical methods were used to determine the ratio of components favorable for the formation of mixed aggregates, the size and the morphology of these aggregates formed in water solutions. The encapsulating and biological properties of the resulting chitosan–calix[4]resorcinarene compositions were studied. The stability of the obtained compositions with the encapsulated substrate was investigated over time. The cytotoxicity study showed their selective effect on the tumor cell line. The design pathway described here can be applied for the formation of various functional drug delivery systems comprising chitosan and macrocycles.

Keywords

calix[4]resorcinarene

The name of the journal

NEW JOURNAL OF CHEMISTRY

URL

https://pubs.rsc.org/en/content/articlelanding/2020/NJ/D0NJ02163F

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=262824&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Kashapov R. Supramolecular assembly of calix[4]resorcinarenes and chitosan for the design of drug nanocontainers with selective effects on diseased cells / R. Kashapov, Yu. Razuvayeva, A. Ziganshina, T. Sergeeva, N. Kashapova, A. Sapunova, A. Voloshina, I. Nizameev, V. Salnikov, L. Zakharova // New J. Chem. – 2020. – 44. – 17854-17863.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=262824&p_lang=2	ru_RU
dc.description.abstract	NEW JOURNAL OF CHEMISTRY	ru_RU
dc.description.abstract	In this paper, the spontaneous formation of nanoparticles through supramolecular interactions between chitosan and sulfonated calix[4]resorcinarenes was demonstrated. A set of physical–chemical methods were used to determine the ratio of components favorable for the formation of mixed aggregates, the size and the morphology of these aggregates formed in water solutions. The encapsulating and biological properties of the resulting chitosan–calix[4]resorcinarene compositions were studied. The stability of the obtained compositions with the encapsulated substrate was investigated over time. The cytotoxicity study showed their selective effect on the tumor cell line. The design pathway described here can be applied for the formation of various functional drug delivery systems comprising chitosan and macrocycles.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Supramolecular assembly of calix[4]resorcinarenes and chitosan for the design of drug nanocontainers with selective effects on diseased cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU