KFU. Card publication. Supraamphiphilic Systems Based on Metallosurfactant and Calix[4]resorcinol: Self-Assembly and Drug Delivery Potential

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

SUPRAAMPHIPHILIC SYSTEMS BASED ON METALLOSURFACTANT AND CALIX[4]RESORCINOL: SELF-ASSEMBLY AND DRUG DELIVERY POTENTIAL

Form of presentation

Articles in international journals and collections

Year of publication

2020

��

��

Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Kashapov R. Supraamphiphilic Systems Based on Metallosurfactant and Calix[4]resorcinol: Self-Assembly and Drug Delivery Potential / R. Kashapov, Y. Razuvayeva, A. Ziganshina, T. Sergeeva, S. Lukashenko, A. Sapunova, A. Voloshina, N. Kashapova, I. Nizameev, V. Salnikov, S. Ziganshina, B. Gareev, L. Zakharova // Inorg. Chem. – 2020. – 59. – 24. – 18276–18286.

Annotation

Metallic amphiphiles are used as building blocks in the construction of nanoscale superstructures, where the hydrophobic effects induce the self-assembly of the nanoparticles of interest. However, the influence of synergizing multiple chemical interactions on an effective design of these structures mostly remains an open question. In this regard, supraamphiphilic systems based on flexible surfactant molecules and rigid macrocycles are being actively developed, but there are few works on the interaction between metallosurfactants and macrocycles. In the present work, the self-assembly and biological properties of a metallosurfactant with calixarene were studied for the first time. The metallosurfactant, a complex between lanthanum nitrate and two 4-aza-1-hexadecylazoniabicyclo[2.2.2]octane bromide units, and calix[4]resorcinol containing sulfonate groups on the upper rim were used to form a novel supraamphiphilic composition. The system formed was studied using a variety of physicochemical methods, including spectrophotometry, NMR, XRF, and dynamic and electrophoretic light scattering. It was found that the most optimal tetraanionic calix[4]resorcinol to dicationic metallosurfactant molar ratio, leading to mixed aggregation upon ion pair complexation, is 2:3. The mixed aggregates formed in the pentamolar concentration range were able to encapsulate hydrophilic substrates, including the anticancer drug cisplatin, the pure form of which is more cytotoxic toward healthy cells than toward diseased cells. Interestingly, the drug loaded into the macrocycle–metallosurfactant particles was less cytotoxic to a healthy Chang liver cell line and more cytotoxic to tumor M-HeLa cells. This selectivity depends on the amount of cisplatin added. The more drug is added to the macrocycle–metallosurfactant composition, the greater the biological activity against cancer cells. Taking into account that the appearance of resistance of cancer cells to drugs, especially to cisplatin, is one of the most important problems in treatment, the results of this work envisage the potential application of a mixed macrocycle–metallosurfactant system for the design of therapeutic cisplatin compositions.

Keywords

calix[4]resorcinol, encapsulation

The name of the journal

Inorganic Chemistry

URL

https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c02833#

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=262822&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Kashapov R. Supraamphiphilic Systems Based on Metallosurfactant and Calix[4]resorcinol: Self-Assembly and Drug Delivery Potential / R. Kashapov, Y. Razuvayeva, A. Ziganshina, T. Sergeeva, S. Lukashenko, A. Sapunova, A. Voloshina, N. Kashapova, I. Nizameev, V. Salnikov, S. Ziganshina, B. Gareev, L. Zakharova // Inorg. Chem. – 2020. – 59. – 24. – 18276–18286.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=262822&p_lang=2	ru_RU
dc.description.abstract	Inorganic Chemistry	ru_RU
dc.description.abstract	Metallic amphiphiles are used as building blocks in the construction of nanoscale superstructures, where the hydrophobic effects induce the self-assembly of the nanoparticles of interest. However, the influence of synergizing multiple chemical interactions on an effective design of these structures mostly remains an open question. In this regard, supraamphiphilic systems based on flexible surfactant molecules and rigid macrocycles are being actively developed, but there are few works on the interaction between metallosurfactants and macrocycles. In the present work, the self-assembly and biological properties of a metallosurfactant with calixarene were studied for the first time. The metallosurfactant, a complex between lanthanum nitrate and two 4-aza-1-hexadecylazoniabicyclo[2.2.2]octane bromide units, and calix[4]resorcinol containing sulfonate groups on the upper rim were used to form a novel supraamphiphilic composition. The system formed was studied using a variety of physicochemical methods, including spectrophotometry, NMR, XRF, and dynamic and electrophoretic light scattering. It was found that the most optimal tetraanionic calix[4]resorcinol to dicationic metallosurfactant molar ratio, leading to mixed aggregation upon ion pair complexation, is 2:3. The mixed aggregates formed in the pentamolar concentration range were able to encapsulate hydrophilic substrates, including the anticancer drug cisplatin, the pure form of which is more cytotoxic toward healthy cells than toward diseased cells. Interestingly, the drug loaded into the macrocycle–metallosurfactant particles was less cytotoxic to a healthy Chang liver cell line and more cytotoxic to tumor M-HeLa cells. This selectivity depends on the amount of cisplatin added. The more drug is added to the macrocycle–metallosurfactant composition, the greater the biological activity against cancer cells. Taking into account that the appearance of resistance of cancer cells to drugs, especially to cisplatin, is one of the most important problems in treatment, the results of this work envisage the potential application of a mixed macrocycle–metallosurfactant system for the design of therapeutic cisplatin compositions.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	calix[4]resorcinol	ru_RU
dc.subject	encapsulation	ru_RU
dc.title	Supraamphiphilic Systems Based on Metallosurfactant and Calix[4]resorcinol: Self-Assembly and Drug Delivery Potential	ru_RU
dc.type	Articles in international journals and collections	ru_RU