KFU. Card publication. Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives

KAZAN
FEDERAL UNIVERSITY

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EFFECT OF PREORGANIZATION AND AMPHIPHILICITY OF CALIX[4]ARENE PLATFORM ON FUNCTIONAL PROPERTIES OF VIOLOGEN DERIVATIVES

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Kashapov R. R. Interaction of mucin with viologen and acetate derivatives of calix[4]resorcinols / R. R..Kashapov, N. E. Kashapova, A. Y. Ziganshina, V. V. Syakaev, V. V. Khutoryanskiy, L. Y. Zakharova // Colloids Surf. B. – 2021. – 208. – 112089.

Annotation

The mucus layer acts as a selective diffusion barrier that has an important effect on the efficiency of drug delivery systems in the human body. In this regard, currently the drug nanocarriers of various sizes and compositions are being widely developed to study their mucoadhesive properties i.e., the ability to interact with mucin. However, the effective interaction of drug composition with mucin does not guarantee the success due to the fact that there is a further barrier in the form of epithelial cells retained by calcium ions under the mucus layer. In this work, the interaction of mucin (porcine gastric mucin) with calixarenes is considered for the first time. The study of interaction between calixarenes, mucin and calcium ions by a complex of physicochemical methods showed that effective interaction with mucin requires cationic fragments, and binding with calcium is realized due to anionic fragments in the calixarene structure. Therefore, the combination of different chemical groups in the structure of drug nanocarrier plays an important role in successful mucosal drug delivery. Taking into account the wide possibilities of synthetic modification of the macrocyclic platform, calixarenes can find the application in the drug delivery across mucous barriers.

Keywords

mucin, viologens, calix[4]resorcinol

The name of the journal

Biointerfaces

URL

https://www.sciencedirect.com/science/article/abs/pii/S0927776521005336?via%3Dihub

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=262818&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Kashapov R. R. Interaction of mucin with viologen and acetate derivatives of calix[4]resorcinols / R. R..Kashapov, N. E. Kashapova, A. Y. Ziganshina, V. V. Syakaev, V. V. Khutoryanskiy, L. Y. Zakharova // Colloids Surf. B. – 2021. – 208. – 112089.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=262818&p_lang=2	ru_RU
dc.description.abstract	Biointerfaces	ru_RU
dc.description.abstract	The mucus layer acts as a selective diffusion barrier that has an important effect on the efficiency of drug delivery systems in the human body. In this regard, currently the drug nanocarriers of various sizes and compositions are being widely developed to study their mucoadhesive properties i.e., the ability to interact with mucin. However, the effective interaction of drug composition with mucin does not guarantee the success due to the fact that there is a further barrier in the form of epithelial cells retained by calcium ions under the mucus layer. In this work, the interaction of mucin (porcine gastric mucin) with calixarenes is considered for the first time. The study of interaction between calixarenes, mucin and calcium ions by a complex of physicochemical methods showed that effective interaction with mucin requires cationic fragments, and binding with calcium is realized due to anionic fragments in the calixarene structure. Therefore, the combination of different chemical groups in the structure of drug nanocarrier plays an important role in successful mucosal drug delivery. Taking into account the wide possibilities of synthetic modification of the macrocyclic platform, calixarenes can find the application in the drug delivery across mucous barriers.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	mucin	ru_RU
dc.subject	viologens	ru_RU
dc.subject	calix[4]resorcinol	ru_RU
dc.title	Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives	ru_RU
dc.type	Articles in international journals and collections	ru_RU