KFU. Card publication. Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives

KAZAN
FEDERAL UNIVERSITY

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EFFECT OF PREORGANIZATION AND AMPHIPHILICITY OF CALIX[4]ARENE PLATFORM ON FUNCTIONAL PROPERTIES OF VIOLOGEN DERIVATIVES

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Kashapov, R. Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives / R. Kashapov, Y. Razuvayeva, A. Ziganshina, A. Sapunova, A. Lyubina, S. Amerhanova, N. Kulik, A. Voloshina, I. Nizameev, V. Salnikov, L. Zakharova // J. Mol. Liq. – 2022. – 345. – 117801.

Annotation

A series of novel amphiphilic cavitands of calix[4]resorcinols with viologen fragments on the upper rim synthesized through a combination of viologen moieties and amphiphilic macrocyclic skeleton is reported. The influence of their structure on self-assembly, solubilization and biological properties was found. The driving force of the self-assembly of the synthesized macrocycles is the hydrophobic interactions of their hydrocarbon chains through additional π-stacking interaction between the aromatic rings of neighboring macrocycle molecules, which is enhanced with an increase in the length of the alkyl chains on the lower rim. The lower hemotoxicity of long-chain viologen macrocycles, relative to viologen surfactant, the ability to bind therapeutic molecules and the selective cytotoxic activity to tumor cells are explicit references to viologen derivatives of calix[4]resorcinols as promising drug nanocontainers.

Keywords

calix[4]resorcines, viologens

The name of the journal

Journal of Molecular Liquids

URL

https://www.sciencedirect.com/science/article/abs/pii/S0167732221025265

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=262817&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Kashapov, R. Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives / R. Kashapov, Y. Razuvayeva, A. Ziganshina, A. Sapunova, A. Lyubina, S. Amerhanova, N. Kulik, A. Voloshina, I. Nizameev, V. Salnikov, L. Zakharova // J. Mol. Liq. – 2022. – 345. – 117801.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=262817&p_lang=2	ru_RU
dc.description.abstract	Journal of Molecular Liquids	ru_RU
dc.description.abstract	A series of novel amphiphilic cavitands of calix[4]resorcinols with viologen fragments on the upper rim synthesized through a combination of viologen moieties and amphiphilic macrocyclic skeleton is reported. The influence of their structure on self-assembly, solubilization and biological properties was found. The driving force of the self-assembly of the synthesized macrocycles is the hydrophobic interactions of their hydrocarbon chains through additional π-stacking interaction between the aromatic rings of neighboring macrocycle molecules, which is enhanced with an increase in the length of the alkyl chains on the lower rim. The lower hemotoxicity of long-chain viologen macrocycles, relative to viologen surfactant, the ability to bind therapeutic molecules and the selective cytotoxic activity to tumor cells are explicit references to viologen derivatives of calix[4]resorcinols as promising drug nanocontainers.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	calix[4]resorcines	ru_RU
dc.subject	viologens	ru_RU
dc.title	Effect of preorganization and amphiphilicity of calix[4]arene platform on functional properties of viologen derivatives	ru_RU
dc.type	Articles in international journals and collections	ru_RU