KFU. Card publication. Cerium(IV) and iron(III) oxides nanoparticles based voltammetric sensor for the sensitive and selective determination of lipoic acid

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CERIUM(IV) AND IRON(III) OXIDES NANOPARTICLES BASED VOLTAMMETRIC SENSOR FOR THE SENSITIVE AND SELECTIVE DETERMINATION OF LIPOIC ACID

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Gimadutdinova Liliya Timurovna, author

Ziyatdinova Guzel Kamilevna, author

Authors, students KFU

Gimadutdinova Liliya Timurovna, author

Bibliographic description in the original language

Ziyatdinova, G. Cerium(IV) and iron(III) oxides nanoparticles based voltammetric sensor for the sensitive and selective determination of lipoic acid / G. Ziyatdinova, L. Gimadutdinova // Sensors. - 2021. - V. 21. - � 22. - Art. 7639. - 13 p.

Annotation

A novel voltammetric sensor based on CeO2 & BULL;Fe2O3 nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provides a 5.6-fold increase of the lipoic acid oxidation currents and a 20 mV anodic shift of the oxidation potential. The best voltammetric parameters have been obtained for the 0.5 mg mL(-1) dispersion of CeO2 & BULL;Fe2O3 NPs. Scanning electron microscopy (SEM) confirms the presence of spherical NPs of 25-60 nm, and their aggregates evenly distributed on the electrode surface and formed porous coverage. This leads to the 4.4-fold increase of the effective surface area vs. bare glassy carbon electrode (GCE). The sensor shows a significantly higher electron transfer rate. Electrooxidation of lipoic acid on CeO2 & BULL;Fe2O3 NPs modified GCE is an irreversible diffusion-controlled pH-independent process occurring with the participation of two electrons. The sensor gives a linear response to lipoic acid in the ranges of 0.075-7.5 and 7.5-100 mu M with the detection limit of 0.053 mu M. The sensor is selective towards lipoic acid in the presence of inorganic ions, ascorbic acid, saccharides, and other S-containing compounds. The sensor developed has been tested on the pharmaceutical dosage forms of lipoic acid.

Keywords

Metal oxide nanoparticles, amperometric sensors, electrooxidation, lipoic acid, pharmaceutical analysis

The name of the journal

Sensors

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119061220&doi=10.3390%2fs21227639&partnerID=40&md5=6b8c00836ea5b2ece2b47468054c433d

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=260607&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gimadutdinova Liliya Timurovna	ru_RU
dc.contributor.author	Ziyatdinova Guzel Kamilevna	ru_RU
dc.contributor.author	Gimadutdinova Liliya Timurovna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Ziyatdinova, G. Cerium(IV) and iron(III) oxides nanoparticles based voltammetric sensor for the sensitive and selective determination of lipoic acid / G. Ziyatdinova, L. Gimadutdinova // Sensors. - 2021. - V. 21. - � 22. - Art. 7639. - 13 p.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=260607&p_lang=2	ru_RU
dc.description.abstract	Sensors	ru_RU
dc.description.abstract	A novel voltammetric sensor based on CeO2 & BULL;Fe2O3 nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provides a 5.6-fold increase of the lipoic acid oxidation currents and a 20 mV anodic shift of the oxidation potential. The best voltammetric parameters have been obtained for the 0.5 mg mL(-1) dispersion of CeO2 & BULL;Fe2O3 NPs. Scanning electron microscopy (SEM) confirms the presence of spherical NPs of 25-60 nm, and their aggregates evenly distributed on the electrode surface and formed porous coverage. This leads to the 4.4-fold increase of the effective surface area vs. bare glassy carbon electrode (GCE). The sensor shows a significantly higher electron transfer rate. Electrooxidation of lipoic acid on CeO2 & BULL;Fe2O3 NPs modified GCE is an irreversible diffusion-controlled pH-independent process occurring with the participation of two electrons. The sensor gives a linear response to lipoic acid in the ranges of 0.075-7.5 and 7.5-100 mu M with the detection limit of 0.053 mu M. The sensor is selective towards lipoic acid in the presence of inorganic ions, ascorbic acid, saccharides, and other S-containing compounds. The sensor developed has been tested on the pharmaceutical dosage forms of lipoic acid.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Metal oxide nanoparticles	ru_RU
dc.subject	amperometric sensors	ru_RU
dc.subject	electrooxidation	ru_RU
dc.subject	lipoic acid	ru_RU
dc.subject	pharmaceutical analysis	ru_RU
dc.title	Cerium(IV) and iron(III) oxides nanoparticles based voltammetric sensor for the sensitive and selective determination of lipoic acid	ru_RU
dc.type	Articles in international journals and collections	ru_RU