KFU. Card publication. The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer

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FEDERAL UNIVERSITY

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THE ROLE OF AUTOPHAGY IN CHEMOTHERAPY RESISTANCE OF CISPLATIN IN OVARIAN CANCER

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Biktagirova Elnara Mauletovna, author

Other authors

Alsoulaiman Lamak , author

Bibliographic description in the original language

Alsoulaiman L. The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer / L. Alsoulaiman, E. Biktagirova, Z. Abramova//CELL DEATH DISCOVERY. - 2021. - Vol.7, Is.SUPPL 1. - P.1-1.

Annotation

Epithelial ovarian cancer is one of the most lethal oncogynecological diseases. Recent researches showed that autophagy induction contributes to the development of the resistance against anticancer drugs. In this work, we evaluated the contribution of the autophagy to cisplatin resistance in the ovarian cancer cell line OVCR8. Atg5 protein plays a critical role in the initiation and elongation stages of autophagy. Effective knockout for ATG5 blocks autophagy induction in the ovarian cancer cell lines, which is confirmed by the lower expression level of the LC-II. We are hypothesizing that in ovarian cancer cells, p62 level is regulated by uncharacterized signaling cascade that senses level of the autophagy. The exact mechanism of this process in autophagy- missing cells is not clear. In addition, in Atg5-knockouted cells, Bcl2 levels were higher than wild-type (p-value < 0.05*) and high level of Bcl2 inhibits apoptosis, and contributes to the resistance to chemotherapeutic drugs, which is consistent with earlier published Results. Autophagy is a promising therapeutic target and characterization of autophagy-mediated chemotherapeutic resistance will pave the way to better treatment of the ovarian cancers.

Keywords

autophagy, resistance, cisplatin, ovarian cancer

The name of the journal

CELL DEATH DISCOVERY

URL

https://www.nature.com/articles/s41420-021-00587-w

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=259228&p_lang=2

Resource files

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F_Cell_Death_Discovery.pdf	0,22	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Biktagirova Elnara Mauletovna	ru_RU
dc.contributor.author	Alsoulaiman Lamak	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Alsoulaiman L. The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer / L. Alsoulaiman, E. Biktagirova, Z. Abramova//CELL DEATH DISCOVERY. - 2021. - Vol.7, Is.SUPPL 1. - P.1-1.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=259228&p_lang=2	ru_RU
dc.description.abstract	CELL DEATH DISCOVERY	ru_RU
dc.description.abstract	Epithelial ovarian cancer is one of the most lethal oncogynecological diseases. Recent researches showed that autophagy induction contributes to the development of the resistance against anticancer drugs. In this work, we evaluated the contribution of the autophagy to cisplatin resistance in the ovarian cancer cell line OVCR8. Atg5 protein plays a critical role in the initiation and elongation stages of autophagy. Effective knockout for ATG5 blocks autophagy induction in the ovarian cancer cell lines, which is confirmed by the lower expression level of the LC-II. We are hypothesizing that in ovarian cancer cells, p62 level is regulated by uncharacterized signaling cascade that senses level of the autophagy. The exact mechanism of this process in autophagy- missing cells is not clear. In addition, in Atg5-knockouted cells, Bcl2 levels were higher than wild-type (p-value < 0.05*) and high level of Bcl2 inhibits apoptosis, and contributes to the resistance to chemotherapeutic drugs, which is consistent with earlier published Results. Autophagy is a promising therapeutic target and characterization of autophagy-mediated chemotherapeutic resistance will pave the way to better treatment of the ovarian cancers.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	autophagy	ru_RU
dc.subject	resistance	ru_RU
dc.subject	cisplatin	ru_RU
dc.subject	ovarian cancer	ru_RU
dc.title	The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer	ru_RU
dc.type	Articles in international journals and collections	ru_RU