KFU. Card publication. Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

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SYNTHESIS AND IN VITRO EVALUATION OF TRIPHENYLPHOSPHONIUM DERIVATIVES OF ACETYLSALICYLIC AND SALICYLIC ACIDS: STRUCTURE-DEPENDENT INTERACTIONS WITH CANCER CELLS, BACTERIA, AND MITOCHONDRIA

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Ishkaeva Rezeda Anasovna, author

Nemtarev Andrey Vladimirovich, author

Bibliographic description in the original language

Tsepaeva O.V, Salikhova T.I, Grigor'eva L.R, D.V. Ponomaryov, T. Dang, R.A. Ishkaeva, T.I. Abdullin, A. Nemtarev, V.F. Mironov.Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria//Medicinal Chemistry Research. - 2021. - Vol.30, Is.4, P. 925-939.

Annotation

Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP) group was proposed. A series of SA and ASA conjugates linked with the TPP group via alkyl chain linker (C3-C10) was synthesized.

Keywords

Acetylsalicylic acid, anticancer activity, anticancer activity, mitochondrial potential, phosphonium salts, salicylic acid

The name of the journal

Medicinal Chemistry Research

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099585446&doi=10.1007%2fs00044-020-02674-6&partnerID=40&md5=1627c1b25d48e80070e773c155ce90cb

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=256887&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ishkaeva Rezeda Anasovna	ru_RU
dc.contributor.author	Nemtarev Andrey Vladimirovich	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Tsepaeva O.V, Salikhova T.I, Grigor'eva L.R, D.V. Ponomaryov, T. Dang, R.A. Ishkaeva, T.I. Abdullin, A. Nemtarev, V.F. Mironov.Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria//Medicinal Chemistry Research. - 2021. - Vol.30, Is.4, P. 925-939.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=256887&p_lang=2	ru_RU
dc.description.abstract	Medicinal Chemistry Research	ru_RU
dc.description.abstract	Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP) group was proposed. A series of SA and ASA conjugates linked with the TPP group via alkyl chain linker (C3-C10) was synthesized.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acetylsalicylic acid	ru_RU
dc.subject	anticancer activity	ru_RU
dc.subject	anticancer activity	ru_RU
dc.subject	mitochondrial potential	ru_RU
dc.subject	phosphonium salts	ru_RU
dc.subject	salicylic acid	ru_RU
dc.title	Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria	ru_RU
dc.type	Articles in international journals and collections	ru_RU