KFU. Card publication. Interfacial Interactions of Phosphatidylglycerol with Oligonucleotide DNA Revealed by Molecular Dynamics Method

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FEDERAL UNIVERSITY

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INTERFACIAL INTERACTIONS OF PHOSPHATIDYLGLYCEROL WITH OLIGONUCLEOTIDE DNA REVEALED BY MOLECULAR DYNAMICS METHOD

Form of presentation

Articles in international journals and collections

Year of publication

2022

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Authors, employees of KFU

Andrianov Grigoriy Vasilevich, author

Ayupov Rustam Khasanovich, author

Zhdanov Renad Ibragimovich, author

Ibragimova Milyausha Yakubovna, author

Other authors

Zaycev Sergey Yurevich, author

Bibliographic description in the original language

Ibragimova M.Y. Interfacial Interactions of Phosphatidylglycerol with Oligonucleotide DNA Revealed by Molecular Dynamics Method / M.Y. Ibragimova, R.Kh. Aupov, G.V. Andrianov, R.I. Zhdanov , S.Yu. Zaitsev // Biointerface Research in Applied Chemistry. - 2022. - V. 12, Issue 3. - C. 3238 - 3246

Annotation

Biointerface Research in Applied Chemistry

Keywords

interfacial interactions; interatomic distances; phosphatidylglycerol; oligonucleotides; DNA-lipid complexes; docking; molecular dynamics

The name of the journal

Biointerface Research in Applied Chemistry

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/165869/F_20695837123.32383246.pdf?sequence=1&isAllowed=y

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=256655&p_lang=2

Resource files

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F_20695837123.32383246.pdf	0,59	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Andrianov Grigoriy Vasilevich	ru_RU
dc.contributor.author	Ayupov Rustam Khasanovich	ru_RU
dc.contributor.author	Zhdanov Renad Ibragimovich	ru_RU
dc.contributor.author	Ibragimova Milyausha Yakubovna	ru_RU
dc.contributor.author	Zaycev Sergey Yurevich	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Ibragimova M.Y. Interfacial Interactions of Phosphatidylglycerol with Oligonucleotide DNA Revealed by Molecular Dynamics Method / M.Y. Ibragimova, R.Kh. Aupov, G.V. Andrianov, R.I. Zhdanov , S.Yu. Zaitsev // Biointerface Research in Applied Chemistry. - 2022. - V. 12, Issue 3. - C. 3238 - 3246	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=256655&p_lang=2	ru_RU
dc.description.abstract	Biointerface Research in Applied Chemistry	ru_RU
dc.description.abstract	An interaction of DNA with lipids is of great interest because of their functions. As fatty acids and lipids can specifically bind to nucleic acids forming a code sequence of the genomic DNA, it is important to study the interaction of the oligonucleotide DNA (dA)20?(dT)20 with phosphatidylglycerol by the molecular dynamics method. Molecular docking has shown that these components form a stable complex with 5.8 kcal/mole binding energy, wherein the lipid is located in the DNA minor groove. This configuration marks 354 atom groups separated by a distance less than 3.4 Ǻ. The van der Waals and hydrophobic interactions play the leading part in the DNA-phospholipid complex stabilization along with hydrogen bonds.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Interfacial Interactions of Phosphatidylglycerol with Oligonucleotide DNA Revealed by Molecular Dynamics Method	ru_RU
dc.type	Articles in international journals and collections	ru_RU