KFU. Card publication. The effect of alpha(1D)-adrenoreceptors selective blockade on the isolated rat heart

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THE EFFECT OF ALPHA(1D)-ADRENORECEPTORS SELECTIVE BLOCKADE ON THE ISOLATED RAT HEART

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Mansur Nur , author

Khabibrakhmanov Insaf Ilkhamovich, author

Bibliographic description in the original language

Khabibrakhmanov I.I. The effect of alpha(1D)-adrenoreceptors selective blockade on the isolated rat heart / I.I. Khabibrakhmanov, A.M. Kuptsova, N.I. Ziyatdinova, N. Mansur, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica, 2020, Vol. 39(7), P. 822-825.

Annotation

Alpha1 -adrenergic receptors (α1 -AR) mediate important adaptive cardiac functions, including physiological hypertrophy, contractility, and protection from multiple injuries, through the activation of various multifactorial signaling cascades. The effects of α1 -AR on chronotropy and coronary circulation of the mammalian heart are poorly understood. The functions regulated by each receptor subtype are also still largely unknown. In addition, scientists often neglect the α1D subtype of the studied receptors due to the low density in cardiomyocytes. The effect of blockade of alpha1D-adrenergic receptors with BMY 7378 on the activity indices of the Langendorff heart of 20-, 6-, 3- and 1-week-old rats was studied. BMY 7378 at a concentration of 10-8 M had a negative chronotropic effect on isolated hearts in rats starting from 1 week of postnatal development. The inotropic reaction of the isolated heart in 20-week-old rats in response to the blocker was absent; while in 6-week-old rats it had a clear negative character. The α1Dadrenergic receptor blocker, BMY, 7378 (10-8 M) causes an increase in the coronary flow of the heart in adult rats and a decrease in 1-week-old rats. At the same time, it does not affect the coronary perfusion of the isolated heart of 3- and 6- week-old rats. An increase in the rate of coronary perfusion in 20-week-old rats indicates a decrease in the tone of the coronary vessels of the heart. In newborn rat pups, BMY 7378 perfusion caused an increase in the tone of the coronary vessels, which led to a decrease in the rate of coronary perfusion. In rats at these stages of postnatal development, α1D-adrenergic receptors may be important in the regulation of the coronary circulation of the heart. The results of the study show that α1 -adrenergic receptors, in addition to providing the effects on coronary vessels, can mediate chrono- and inotropic effects on the rat heart in postnatal ontogenesis.

Keywords

rat, isolated heart, alpha 1D-adrenergic receptors, BMY7378

The name of the journal

Archivos Venezolanos de Farmacología y Terapéutica

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=253923&p_lang=2

Resource files

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Mansur Nur	ru_RU
dc.contributor.author	Khabibrakhmanov Insaf Ilkhamovich	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Khabibrakhmanov I.I. The effect of alpha(1D)-adrenoreceptors selective blockade on the isolated rat heart / I.I. Khabibrakhmanov, A.M. Kuptsova, N.I. Ziyatdinova, N. Mansur, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica, 2020, Vol. 39(7), P. 822-825.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=253923&p_lang=2	ru_RU
dc.description.abstract	Archivos Venezolanos de Farmacología y Terapéutica	ru_RU
dc.description.abstract	Alpha1 -adrenergic receptors (α1 -AR) mediate important adaptive cardiac functions, including physiological hypertrophy, contractility, and protection from multiple injuries, through the activation of various multifactorial signaling cascades. The effects of α1 -AR on chronotropy and coronary circulation of the mammalian heart are poorly understood. The functions regulated by each receptor subtype are also still largely unknown. In addition, scientists often neglect the α1D subtype of the studied receptors due to the low density in cardiomyocytes. The effect of blockade of alpha1D-adrenergic receptors with BMY 7378 on the activity indices of the Langendorff heart of 20-, 6-, 3- and 1-week-old rats was studied. BMY 7378 at a concentration of 10-8 M had a negative chronotropic effect on isolated hearts in rats starting from 1 week of postnatal development. The inotropic reaction of the isolated heart in 20-week-old rats in response to the blocker was absent; while in 6-week-old rats it had a clear negative character. The α1Dadrenergic receptor blocker, BMY, 7378 (10-8 M) causes an increase in the coronary flow of the heart in adult rats and a decrease in 1-week-old rats. At the same time, it does not affect the coronary perfusion of the isolated heart of 3- and 6- week-old rats. An increase in the rate of coronary perfusion in 20-week-old rats indicates a decrease in the tone of the coronary vessels of the heart. In newborn rat pups, BMY 7378 perfusion caused an increase in the tone of the coronary vessels, which led to a decrease in the rate of coronary perfusion. In rats at these stages of postnatal development, α1D-adrenergic receptors may be important in the regulation of the coronary circulation of the heart. The results of the study show that α1 -adrenergic receptors, in addition to providing the effects on coronary vessels, can mediate chrono- and inotropic effects on the rat heart in postnatal ontogenesis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	rat	ru_RU
dc.subject	isolated heart	ru_RU
dc.subject	alpha 1D-adrenergic receptors	ru_RU
dc.subject	BMY7378	ru_RU
dc.title	The effect of alpha(1D)-adrenoreceptors selective blockade on the isolated rat heart	ru_RU
dc.type	Articles in international journals and collections	ru_RU