KFU. Card publication. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

DISRUPTING TUMOR ONSET AND GROWTH VIA SELECTIVE CELL TAGGING (SECT) THERAPY

Form of presentation

Articles in international journals and collections

Year of publication

2021

Язык

английский

Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Nasibullin Igor Olegovich, author

Tanaka Kacunori , author

Other authors

Nakao Yoichi , author

Onoe Hirotaka , author

Tahara Tsuyoshi , author

Tsubokura Kazuki , author

Urano Sayaka , author

Vong Kenward , author

Watanabe Yasuyoshi , author

Bibliographic description in the original language

Vong, K. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy / K. Vong, T. Tahara, S. Urano, I. Nasibullin, K. Tsubokura, Y. Nakao, A. Kurbangalieva, H. Onoe, Y. Watanabe, K. Tanaka // Sci. Adv. – 2021. – V. 7, № 17. – Art. № eabg4038.

Annotation

This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)–based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic–Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.

Keywords

cell tagging (SeCT) therapy, glycosylated artificial metalloenzyme, protein labeling,

The name of the journal

Science advances

URL

https://www.science.org/doi/10.1126/sciadv.abg4038

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=253584&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Nasibullin Igor Olegovich	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.contributor.author	Nakao Yoichi	ru_RU
dc.contributor.author	Onoe Hirotaka	ru_RU
dc.contributor.author	Tahara Tsuyoshi	ru_RU
dc.contributor.author	Tsubokura Kazuki	ru_RU
dc.contributor.author	Urano Sayaka	ru_RU
dc.contributor.author	Vong Kenward	ru_RU
dc.contributor.author	Watanabe Yasuyoshi	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Vong, K. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy / K. Vong, T. Tahara, S. Urano, I. Nasibullin, K. Tsubokura, Y. Nakao, A. Kurbangalieva, H. Onoe, Y. Watanabe, K. Tanaka // Sci. Adv. – 2021. – V. 7, № 17. – Art. № eabg4038.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=253584&p_lang=2	ru_RU
dc.description.abstract	Science advances	ru_RU
dc.description.abstract	This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)–based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic–Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	cell tagging (SeCT) therapy	ru_RU
dc.subject	glycosylated artificial metalloenzyme	ru_RU
dc.subject	protein labeling	ru_RU
dc.subject		ru_RU
dc.title	Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy	ru_RU
dc.type	Articles in international journals and collections	ru_RU