KFU. Card publication. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents

KAZAN
FEDERAL UNIVERSITY

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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-QUINOLYL-1,3-TROPOLON DERIVATIVES AS NEW ANTI-CANCER AGENTS

Form of presentation

Articles in international journals and collections

Year of publication

2021

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Authors, employees of KFU

Bulatov Emil Rafaelevich, author

Bumber Yanis Alekseevich, author

Serebriyskiy Ilya Genrikhovich, author

Topchu Yuliya Alekseevna, author

Authors, postgraduates KFU

Mazitova Aleksandra Maratovna, postgraduate kfu

Bibliographic description in the original language

Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571 (Q1 SJR 0,740 IF 3.119)

Annotation

Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.

Keywords

Design, synthesis, and biological, 2-quinolyl-1,3-tropolon, anti-cancer agents

The name of the journal

RSC Advances

URL

https://pubs.rsc.org/en/content/articlelanding/2021/ra/d0ra10610k#!divAbstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=246347&p_lang=2

Resource files

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RSC_Advances.pdf	1,56	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bulatov Emil Rafaelevich	ru_RU
dc.contributor.author	Bumber Yanis Alekseevich	ru_RU
dc.contributor.author	Serebriyskiy Ilya Genrikhovich	ru_RU
dc.contributor.author	Topchu Yuliya Alekseevna	ru_RU
dc.contributor.author	Mazitova Aleksandra Maratovna	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Gusakov, E. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents /A. Gusakov, Iu. A. Topchu, A. M. Mazitova, I. V. Dorogan, E. R. Bulatov, I. G. Serebriiskii, Z. I. Abramova, I. O. Tupaeva, O. P. Demidov, D. N. Toan, T. D. Lam, D. N. Bang, Y.A. Boumber, Y. A. Sayapin, V. I. Minkin. // RSC Advances.- 2021.- V.11.-P.4555-4571 (Q1 SJR 0,740 IF 3.119)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=246347&p_lang=2	ru_RU
dc.description.abstract	RSC Advances	ru_RU
dc.description.abstract	Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i?k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i?k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Design	ru_RU
dc.subject	synthesis	ru_RU
dc.subject	and biological	ru_RU
dc.subject	2-quinolyl-1	ru_RU
dc.subject	3-tropolon	ru_RU
dc.subject	anti-cancer agents	ru_RU
dc.title	Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolon derivatives as new anti-cancer agents	ru_RU
dc.type	Articles in international journals and collections	ru_RU