KFU. Card publication. hanges in the ratios of stable nitric oxide metabolites in the exhaled breath condensate in patients with COPD during antioxidant therapy.

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HANGES IN THE RATIOS OF STABLE NITRIC OXIDE METABOLITES IN THE EXHALED BREATH CONDENSATE IN PATIENTS WITH COPD DURING ANTIOXIDANT THERAPY.

Form of presentation

Conference proceedings in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Kubysheva Nailya Iskhakovna, author

Other authors

Glukhova M. , author

Klimanov Igor , author

Murakaeva L. , author

Nikitina Lidiya , author

Popova Nataliia , author

Soodaeva Svetlana , author

Bibliographic description in the original language

Klimanov, I. A., Soodaeva, S. K., Popova, N. A., Li, T. V., Kubysheva, N. I., Murakaeva, L. R., GlukhovaM.V., & Nikitina, L. Y. (2019). Changes in the ratios of stable nitric oxide metabolites in the exhaled breath condensate in patients with COPD during antioxidant therapy. European Respiratory Journal 2019; 54: Suppl. 63: PA4106.

Annotation

European Respiratory Journal 2019; 54: Suppl. 63

Keywords

Biomarkers, nitric oxide, COPD - mechanism

The name of the journal

European Respiratory Journal 2019; 54: Suppl. 63

URL

https://erj.ersjournals.com/content/54/suppl_63/PA4106.abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=244538&p_lang=2

Resource files

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F_Changes_in_the_ratios_of_stable_NO_metabolites_in_the_EBC_in_patients_with_COPD_during_antioxidant_therapy.pdf	0,26	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kubysheva Nailya Iskhakovna	ru_RU
dc.contributor.author	Glukhova M.	ru_RU
dc.contributor.author	Klimanov Igor	ru_RU
dc.contributor.author	Murakaeva L.	ru_RU
dc.contributor.author	Nikitina Lidiya	ru_RU
dc.contributor.author	Popova Nataliia	ru_RU
dc.contributor.author	Soodaeva Svetlana	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Klimanov, I. A., Soodaeva, S. K., Popova, N. A., Li, T. V., Kubysheva, N. I., Murakaeva, L. R., GlukhovaM.V., & Nikitina, L. Y. (2019). Changes in the ratios of stable nitric oxide metabolites in the exhaled breath condensate in patients with COPD during antioxidant therapy. European Respiratory Journal 2019; 54: Suppl. 63: PA4106.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=244538&p_lang=2	ru_RU
dc.description.abstract	European Respiratory Journal 2019; 54: Suppl. 63	ru_RU
dc.description.abstract	The Study Aim: to investigate the correlations between stable nitric oxide metabolites in exhaled breath condensate (EBC) in patients with COPD during antioxidant therapy. Materials and Methods: The study included 88 patients: group 1 – COPD, stage I (GOLD spirometry classification) (n=47), group 2 – COPD, stage II (n=41). The control group consisted of 35 healthy volunteers. In all groups ECB samples were collected. In the experimental groups ECB was collected before and after the course of antioxidant therapy with N-acetylcysteine (NAC), 600 mg daily for 30 days. The EBC concentrations of nitrates (NO3-) and nitrites(NO2-) were determined by spectrophotometric method using the Griess reagent. The correlations between ECB NO3- and NO2- levels were studied during antioxidant therapy therapy. Results: It was found that NO3- and NO2- ECB levels in both experimental groups were significantly increased compared with control values. Control group showed strong positive correlation between the studied parameters (r = 0,98; p = 0,001) and linear coefficient k = 2,13 (k = {NO3-} / {NO2-}). There were no any correlations of studied parameters in both groups of COPD patients. However, significant linear correlation between NO3- and NO2- ECB levels (r = 0,87; p = 0.003) with a linear coefficient k = 2,5 was observed in group 1 after the NAC treatment. In COPD patients no significant changes in total NO3-/NO2- ECB levels were revealed after the antioxidant therapy therapy. Conclusion: NO3- and NO2- ECB levels reflect changes in nitric oxide cycle and can serve as a marker of antioxidant therapy efficacy.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Biomarkers	ru_RU
dc.subject	nitric oxide	ru_RU
dc.subject	COPD - mechanism	ru_RU
dc.title	hanges in the ratios of stable nitric oxide metabolites in the exhaled breath condensate in patients with COPD during antioxidant therapy.	ru_RU
dc.type	Conference proceedings in international journals and collections	ru_RU