| Form of presentation | Conference proceedings in international journals and collections |
| Year of publication | 2020 |
| Язык | английский |
|
Kubysheva Nailya Iskhakovna, author
|
|
Klimanov Igor , author
Nikitina Lidiya , author
Novoselov Vladimir , author
Popova Nataliia , author
Soodaeva Svetlana , author
|
| Bibliographic description in the original language |
Soodaeva, S. K., Kubysheva, N. I., Klimanov, I. A., Nikitina, L. Y., Popova, N. A., Li, T. V., Novoselov, V. I. (2020). The change of the activity of the blood-salivary barrier (BSB) in patients with COPD.
European Respiratory Journal 2020 56: 1040. |
| Annotation |
European Respiratory Journal 2020 56: 1040. |
| Keywords |
Biomarkers, COPD, inflammation |
| The name of the journal |
European Respiratory Journal 2020 56: 1040.
|
| URL |
https://erj.ersjournals.com/content/56/suppl_64/1040 |
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=244365&p_lang=2 |
| Resource files | |
|
|
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Kubysheva Nailya Iskhakovna |
ru_RU |
| dc.contributor.author |
Klimanov Igor |
ru_RU |
| dc.contributor.author |
Nikitina Lidiya |
ru_RU |
| dc.contributor.author |
Novoselov Vladimir |
ru_RU |
| dc.contributor.author |
Popova Nataliia |
ru_RU |
| dc.contributor.author |
Soodaeva Svetlana |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Soodaeva, S. K., Kubysheva, N. I., Klimanov, I. A., Nikitina, L. Y., Popova, N. A., Li, T. V., Novoselov, V. I. (2020). The change of the activity of the blood-salivary barrier (BSB) in patients with COPD.
European Respiratory Journal 2020 56: 1040. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=244365&p_lang=2 |
ru_RU |
| dc.description.abstract |
European Respiratory Journal 2020 56: 1040. |
ru_RU |
| dc.description.abstract |
Objective: To investigate the content of calcium (Ca), magnesium (Mg), iron (Fe) in serum and saliva in patients with moderate to severe COPD during the exacerbation.
The levels of Ca, Mg, Fe in saliva and serum were studied in 97 patients with COPDII and COPDIII during exacerbation and 28 healthy non-smokers volunteers. The activity BSB was determined by the value of the distribution coefficient (CR).
The serum Ca, Mg and Fe levels in the examined patients with COPD did not differ from the control group. A decrease in the concentration of salivary Mg was found in patients with COPDII (2.2 times) and COPDIII (2.7 times) compared with control (0.63?0.03 mmol/l, p <0.05). The concentration of Fe in saliva increased significantly in COPDII (2 times) and COPDIII (1.6 times) compared with control (5.94?0.21 μmol/l). The content of salivary and circulating Ca did not differ from the control. A positive correlation was established between the content of salivary Mg and FEV1 with COPDII (r=0.39, p<0.05) and COPDIII (r=0.46, p<0.05). In addition, a positive correlation was revealed between the content of circulating Mg and FEV1 in patients with COPDIII (r=0.42, p <0.05). A negative association between the concentration of Fe in saliva and FEV1 in COPDII (r=–0.46, p<0.05) was found. A positive correlation was established between the Fe content in the blood and FEV1 in patients with COPDIII (r=0.39, p<0.05). CR for Mg increased progressively with the severity of the disease. A decrease in CR for Fe in COPDII by 49.8% and by 36.9% in patients with COPDIII was recorded.
The changes in the BSB activity can be one of the links in the pathogenesis of chronic inflammation and bronchial obstruction. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Biomarkers |
ru_RU |
| dc.subject |
COPD |
ru_RU |
| dc.subject |
inflammation |
ru_RU |
| dc.title |
The change of the activity of the blood-salivary barrier (BSB) in patients with COPD. |
ru_RU |
| dc.type |
Conference proceedings in international journals and collections |
ru_RU |
|
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