KFU. Card publication. The novel calix[4]resorcinarene-PEG conjugate: Synthesis, self-association and encapsulation properties

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FEDERAL UNIVERSITY

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THE NOVEL CALIX[4]RESORCINARENE-PEG CONJUGATE: SYNTHESIS, SELF-ASSOCIATION AND ENCAPSULATION PROPERTIES

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Gubaydullin Aydar Timergalievich, author

Konovalov Aleksandr Ivanovich, author

Morozova Yuliya Ernestovna, author

Sayfina Alina Fuadovna, author

Shalaeva Yana Viktorovna, author

Other authors

Bazanova Olga Borisovna, author

Voloshina Aleksandra Dmitrievna, author

Kadirov Marsil Kakhirovich, author

Nizameev Irek Rashatovich, author

Sapunova Anastasiya Sergeevna, author

Syakaev Viktor Vasilevich, author

Authors, postgraduates KFU

Shumatbaeva Alina Marselovna, postgraduate kfu

Bibliographic description in the original language

A. M. Shumatbaeva, The novel calix[4]resorcinarene-PEG conjugate: Synthesis, self-association and encapsulation properties / A. M. Shumatbaeva, Ju. E. Morozova, Ya.V. Shalaeva, A.T. Gubaidullin, A.F. Saifina, V.V. Syakaev, O.B. Bazanova, A.S. Sapunova, A.D. Voloshina, I. R. Nizameev, M.K. Kadirov, A. I. Konovalov. // Colloids and Surfaces A. - 2019. – V.570. – P. 182–190. DOI: 10.1016/j.colsurfa.2019.03.021

Annotation

The synthesis and study of self-association and encapsulation ability of new low toxic conjugate of tetra-phenyleneoxypentylcalix[4]resorcinarene and methoxy-poly(ethylene glycole) (C 5 OPh-mPEG) were described. The conjugate is characterized by 1 H, 13 C NMR, FT-IR, MS, SLS methods. In an aqueous solution the conjugate form multimicellar nanoparticles with low polydispersity value (0.1, DLS method). The self-association of the conjugate was studied by DLS, fluorescence, fluorescence anisotropy method, TEM, and SAXS methods. The SAXS data were detailed analyzed, and the conjugate associates structure as ellipsoidal core-shell particles was proposed. The encapsulation efficiency is a result of the affinity of the conjugate low rim substituents to substrates and reaches of 39.8, 26.7, and 28.9% toward naproxen, ibuprofen and doxorubicin drugs, respectively.

Keywords

Calix[4]resorcinarene, PEG, conjugation, SAXS, encapsulation

The name of the journal

Colloids and Surfaces A: Physicochemical and Engineering Aspects

URL

https://www.sciencedirect.com/science/article/pii/S0927775719302092?via%3Dihub

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241493&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gubaydullin Aydar Timergalievich	ru_RU
dc.contributor.author	Konovalov Aleksandr Ivanovich	ru_RU
dc.contributor.author	Morozova Yuliya Ernestovna	ru_RU
dc.contributor.author	Sayfina Alina Fuadovna	ru_RU
dc.contributor.author	Shalaeva Yana Viktorovna	ru_RU
dc.contributor.author	Bazanova Olga Borisovna	ru_RU
dc.contributor.author	Voloshina Aleksandra Dmitrievna	ru_RU
dc.contributor.author	Kadirov Marsil Kakhirovich	ru_RU
dc.contributor.author	Nizameev Irek Rashatovich	ru_RU
dc.contributor.author	Sapunova Anastasiya Sergeevna	ru_RU
dc.contributor.author	Syakaev Viktor Vasilevich	ru_RU
dc.contributor.author	Shumatbaeva Alina Marselovna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	A. M. Shumatbaeva, The novel calix[4]resorcinarene-PEG conjugate: Synthesis, self-association and encapsulation properties / A. M. Shumatbaeva, Ju. E. Morozova, Ya.V. Shalaeva, A.T. Gubaidullin, A.F. Saifina, V.V. Syakaev, O.B. Bazanova, A.S. Sapunova, A.D. Voloshina, I. R. Nizameev, M.K. Kadirov, A. I. Konovalov. // Colloids and Surfaces A. - 2019. – V.570. – P. 182–190. DOI: 10.1016/j.colsurfa.2019.03.021	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241493&p_lang=2	ru_RU
dc.description.abstract	Colloids and Surfaces A: Physicochemical and Engineering Aspects	ru_RU
dc.description.abstract	The synthesis and study of self-association and encapsulation ability of new low toxic conjugate of tetra-phenyleneoxypentylcalix[4]resorcinarene and methoxy-poly(ethylene glycole) (C 5 OPh-mPEG) were described. The conjugate is characterized by 1 H, 13 C NMR, FT-IR, MS, SLS methods. In an aqueous solution the conjugate form multimicellar nanoparticles with low polydispersity value (0.1, DLS method). The self-association of the conjugate was studied by DLS, fluorescence, fluorescence anisotropy method, TEM, and SAXS methods. The SAXS data were detailed analyzed, and the conjugate associates structure as ellipsoidal core-shell particles was proposed. The encapsulation efficiency is a result of the affinity of the conjugate low rim substituents to substrates and reaches of 39.8, 26.7, and 28.9% toward naproxen, ibuprofen and doxorubicin drugs, respectively.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Calix[4]resorcinarene	ru_RU
dc.subject	PEG	ru_RU
dc.subject	conjugation	ru_RU
dc.subject	SAXS	ru_RU
dc.subject	encapsulation	ru_RU
dc.title	The novel calix[4]resorcinarene-PEG conjugate: Synthesis, self-association and encapsulation properties	ru_RU
dc.type	Articles in international journals and collections	ru_RU