KFU. Card publication. Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles

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FORMATION OF COOPERATIVE AMIDOAMINOCALIXRESORCINARENE &NDASH; METHOTREXATE NANOSIZED AGGREGATES IN AN AQUEOUS SOLUTION AND ON THE SURFACE OF GOLD NANOPARTICLES

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Ermakova Alina Marselovna, author

Konovalov Aleksandr Ivanovich, author

Morozova Yuliya Ernestovna, author

Shalaeva Yana Viktorovna, author

Other authors

Kadirov Marsil Kakhirovich, author

Kazakova Ella Khatibovna, author

Nizameev Irek Rashatovich, author

Syakaev Viktor Vasilevich, author

Bibliographic description in the original language

Shalaeva Ya.V., Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles. // Shalaeva Ya.V., Morozova Ju. E., Syakaev V. V., Ermakova A. M., Nizameev I. R., Kadirov M. K., Kazakova E. Kh., Konovalov A. I. // Supramol. Chem. – 2018. – V. 30. – P. 901-910. DOI: 10.1080/10610278.2018.1467015

Annotation

Cooperative nanoscale associates of amido(dimethylamino) calixresorcinarenes with pentyl (C5) and undecyl (C11) substituents on lower rim with antitumor drug-methotrexate (MTX) in aqueous solution and on the surface of gold nanoparticles C5@Au and C11@Au were formed. The formation of nanoparticles was investigated by 1 H NMR, NMR FT-PGSE, 2D NOESY, DLS, TEM, spectrophotometry, fluorimetry. It was found that during the interaction of C5 or C11 macrocycles with MTX in aqueous solution, the latter generates dissociation of macrocycles self-associates with formation of cooperative macrocycle–MTX associates of smaller size due to multiple non-covalent interactions, which leads to increase in fluorescence intensity of MTX. In contrast, binding of MTX by macrocyclic associates preorganized as bilayer on surface of gold nanoparticles through electrostatic interactions induces aggregation of C5@Au-MTX or C11@Au-MTX associates, which results in quenching of MTX fluorescence in solution. Such particles have possible potential in the field of binding and delivery of antitumor drugs.

Keywords

calixresorcinarene, supramolecular aggregates, gold nanoparticles, methotrexate

The name of the journal

Supramolecular Chemistry

URL

https://www.tandfonline.com/doi/full/10.1080/10610278.2018.1467015

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241484&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ermakova Alina Marselovna	ru_RU
dc.contributor.author	Konovalov Aleksandr Ivanovich	ru_RU
dc.contributor.author	Morozova Yuliya Ernestovna	ru_RU
dc.contributor.author	Shalaeva Yana Viktorovna	ru_RU
dc.contributor.author	Kadirov Marsil Kakhirovich	ru_RU
dc.contributor.author	Kazakova Ella Khatibovna	ru_RU
dc.contributor.author	Nizameev Irek Rashatovich	ru_RU
dc.contributor.author	Syakaev Viktor Vasilevich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Shalaeva Ya.V., Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles. // Shalaeva Ya.V., Morozova Ju. E., Syakaev V. V., Ermakova A. M., Nizameev I. R., Kadirov M. K., Kazakova E. Kh., Konovalov A. I. // Supramol. Chem. – 2018. – V. 30. – P. 901-910. DOI: 10.1080/10610278.2018.1467015	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241484&p_lang=2	ru_RU
dc.description.abstract	Supramolecular Chemistry	ru_RU
dc.description.abstract	Cooperative nanoscale associates of amido(dimethylamino) calixresorcinarenes with pentyl (C5) and undecyl (C11) substituents on lower rim with antitumor drug-methotrexate (MTX) in aqueous solution and on the surface of gold nanoparticles C5@Au and C11@Au were formed. The formation of nanoparticles was investigated by 1 H NMR, NMR FT-PGSE, 2D NOESY, DLS, TEM, spectrophotometry, fluorimetry. It was found that during the interaction of C5 or C11 macrocycles with MTX in aqueous solution, the latter generates dissociation of macrocycles self-associates with formation of cooperative macrocycle–MTX associates of smaller size due to multiple non-covalent interactions, which leads to increase in fluorescence intensity of MTX. In contrast, binding of MTX by macrocyclic associates preorganized as bilayer on surface of gold nanoparticles through electrostatic interactions induces aggregation of C5@Au-MTX or C11@Au-MTX associates, which results in quenching of MTX fluorescence in solution. Such particles have possible potential in the field of binding and delivery of antitumor drugs.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	calixresorcinarene	ru_RU
dc.subject	supramolecular aggregates	ru_RU
dc.subject	gold nanoparticles	ru_RU
dc.subject	methotrexate	ru_RU
dc.title	Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles	ru_RU
dc.type	Articles in international journals and collections	ru_RU