KFU. Card publication. Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

KAZAN
FEDERAL UNIVERSITY

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NANOCONJUGATES OF A CALIXRESORCINARENE DERIVATIVE WITH METHOXY POLY(ETHYLENE GLYCOL) FRAGMENTS FOR DRUG ENCAPSULATION

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Antipin Igor Sergeevich, author

Gubaydullin Aydar Timergalievich, author

Ermakova Alina Marselovna, author

Konovalov Aleksandr Ivanovich, author

Morozova Yuliya Ernestovna, author

Shalaeva Yana Viktorovna, author

Other authors

Bazanova Olga Borisovna, author

Voloshina Aleksandra Dmitrievna, author

Zobov Vladimir Vasilevich, author

Nizameev Irek Rashatovich, author

Syakaev Viktor Vasilevich, author

Bibliographic description in the original language

Ermakova A., Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation / Ermakova A., Morozova Ju., Shalaeva Ya., Syakaev V., Gubaidullin A., Voloshina A., Zobov V., Nizameev I., Bazanova O., Antipin I., Konovalov A. // Beilstein J. Nanotechnol. – 2018. – V. 9. – P. 2057-2070. DOI:10.3762/bjnano.9.195

Annotation

In order to obtain a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecyl-calixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms nanoassociates that are able to encapsulate organic substrates of different hydrophobicity, including drugs (doxorubicin, naproxen, ibuprofen, quercetin). The micelles of the macrocycle slowed down the release of the hydrophilic substrates in vitro. In physiological sodium chloride solution and phosphate-buffered saline, the micelles of the macrocycle acquire thermoresponsive properties and exhibit a temperature-controlled release of doxorubicin in vitro. The combination of the low toxicity and the encapsulation properties of the obtained calixresorcinarene–mPEG conjugate shows promising potential for the use as a supramolecular drug-delivery system.

Keywords

calixresorcinarene, drug encapsulation, hemotoxicity, methoxy poly(ethylene glycol), temperature-controlled release

The name of the journal

BEILSTEIN JOURNAL OF NANOTECHNOLOGY

URL

https://www.beilstein-journals.org/bjnano/articles/9/195

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241482&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Antipin Igor Sergeevich	ru_RU
dc.contributor.author	Gubaydullin Aydar Timergalievich	ru_RU
dc.contributor.author	Ermakova Alina Marselovna	ru_RU
dc.contributor.author	Konovalov Aleksandr Ivanovich	ru_RU
dc.contributor.author	Morozova Yuliya Ernestovna	ru_RU
dc.contributor.author	Shalaeva Yana Viktorovna	ru_RU
dc.contributor.author	Bazanova Olga Borisovna	ru_RU
dc.contributor.author	Voloshina Aleksandra Dmitrievna	ru_RU
dc.contributor.author	Zobov Vladimir Vasilevich	ru_RU
dc.contributor.author	Nizameev Irek Rashatovich	ru_RU
dc.contributor.author	Syakaev Viktor Vasilevich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Ermakova A., Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation / Ermakova A., Morozova Ju., Shalaeva Ya., Syakaev V., Gubaidullin A., Voloshina A., Zobov V., Nizameev I., Bazanova O., Antipin I., Konovalov A. // Beilstein J. Nanotechnol. – 2018. – V. 9. – P. 2057-2070. DOI:10.3762/bjnano.9.195	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241482&p_lang=2	ru_RU
dc.description.abstract	BEILSTEIN JOURNAL OF NANOTECHNOLOGY	ru_RU
dc.description.abstract	In order to obtain a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecyl-calixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms nanoassociates that are able to encapsulate organic substrates of different hydrophobicity, including drugs (doxorubicin, naproxen, ibuprofen, quercetin). The micelles of the macrocycle slowed down the release of the hydrophilic substrates in vitro. In physiological sodium chloride solution and phosphate-buffered saline, the micelles of the macrocycle acquire thermoresponsive properties and exhibit a temperature-controlled release of doxorubicin in vitro. The combination of the low toxicity and the encapsulation properties of the obtained calixresorcinarene–mPEG conjugate shows promising potential for the use as a supramolecular drug-delivery system.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	calixresorcinarene	ru_RU
dc.subject	drug encapsulation	ru_RU
dc.subject	hemotoxicity	ru_RU
dc.subject	methoxy poly(ethylene glycol)	ru_RU
dc.subject	temperature-controlled release	ru_RU
dc.title	Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation	ru_RU
dc.type	Articles in international journals and collections	ru_RU