KFU. Card publication. Design of N-Methyl-d-Glucamine-Based Resorcin[4]arene Nanoparticles for Enhanced assembly and encapsulation activities Effects / R. R. Kashapov, Y. S. Razuvayeva

- RUS
- 中文
- ES

DESIGN OF N-METHYL-D-GLUCAMINE-BASED RESORCIN[4]ARENE NANOPARTICLES FOR ENHANCED ASSEMBLY AND ENCAPSULATION ACTIVITIES EFFECTS / R. R. KASHAPOV, Y. S. RAZUVAYEVA

Form of presentation

Articles in international journals and collections

Year of publication

2020

��

��

Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Kashapov R. R. Design of N-Methyl-d-Glucamine-Based Resorcin[4]arene Nanoparticles for Enhanced assembly and encapsulation activities Effects / R. R. Kashapov, Y. S. Razuvayeva, A. Y. Ziganshina, R. K. Mukhitova, A. S. Sapunova, A. D. Voloshina, I. R. Nizameev, M. K. Kadirov, L. Ya. Zakharova // Mol. Pharmaceutics. – 2020. – 17. – 40-49.

Annotation

The addition of specific chemical groups in a macrocycle structure influences its functional properties and, consequently, can provide new possibilities, among which are aggregation properties, water solubility, biocompatibility, stimuli response, biological activity, etc. Herein, we report synthesis of new resorcin[4]arene with N-methyl-d-glucamine groups on the upper rim and n-decyl chains on the lower rim, an investigation of its self-assembly behavior in aqueous media, and its use as a building block for the formation of drug nanocontainer. N-methyl-d-glucamine fragments in the resorcin[4]arene structure promote higher stability in solutions, simplification of self-aggregation, and increased biological activity. Antimicrobial and hemolytic activity assessment revealed that this resorcin[4]arene obtained is nontoxic. The study of cell penetration was carried out with both free and encapsulated doxorubicin (DOX). Surprisingly, DOX-loaded macrocycle aggregates are more efficient in causing apoptosis in human cancer cell line. Conceivably, this knowledge will help in the rational design of DOX combination for novel drug-administration strategies in cancer treatment.

Keywords

resorcin[4]arene, nanocarrier, doxorubicin

The name of the journal

Molecular Pharmaceutics

URL

https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00599

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241115&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Kashapov R. R. Design of N-Methyl-d-Glucamine-Based Resorcin[4]arene Nanoparticles for Enhanced assembly and encapsulation activities Effects / R. R. Kashapov, Y. S. Razuvayeva, A. Y. Ziganshina, R. K. Mukhitova, A. S. Sapunova, A. D. Voloshina, I. R. Nizameev, M. K. Kadirov, L. Ya. Zakharova // Mol. Pharmaceutics. – 2020. – 17. – 40-49.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241115&p_lang=2	ru_RU
dc.description.abstract	Molecular Pharmaceutics	ru_RU
dc.description.abstract	The addition of specific chemical groups in a macrocycle structure influences its functional properties and, consequently, can provide new possibilities, among which are aggregation properties, water solubility, biocompatibility, stimuli response, biological activity, etc. Herein, we report synthesis of new resorcin[4]arene with N-methyl-d-glucamine groups on the upper rim and n-decyl chains on the lower rim, an investigation of its self-assembly behavior in aqueous media, and its use as a building block for the formation of drug nanocontainer. N-methyl-d-glucamine fragments in the resorcin[4]arene structure promote higher stability in solutions, simplification of self-aggregation, and increased biological activity. Antimicrobial and hemolytic activity assessment revealed that this resorcin[4]arene obtained is nontoxic. The study of cell penetration was carried out with both free and encapsulated doxorubicin (DOX). Surprisingly, DOX-loaded macrocycle aggregates are more efficient in causing apoptosis in human cancer cell line. Conceivably, this knowledge will help in the rational design of DOX combination for novel drug-administration strategies in cancer treatment.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	resorcin[4]arene	ru_RU
dc.subject	nanocarrier	ru_RU
dc.subject	doxorubicin	ru_RU
dc.title	Design of N-Methyl-d-Glucamine-Based Resorcin[4]arene Nanoparticles for Enhanced assembly and encapsulation activities Effects / R. R. Kashapov, Y. S. Razuvayeva	ru_RU
dc.type	Articles in international journals and collections	ru_RU