KFU. Card publication. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene

KAZAN
FEDERAL UNIVERSITY

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DOXORUBICIN DELIVERY BY POLYMER NANOCARRIER BASED ON N-METHYLGLUCAMINE RESORCINARENE

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Ziganshina Albina Yulduzovna, author

Bibliographic description in the original language

Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161.

Annotation

Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.

Keywords

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The name of the journal

Supramolecular Chemistry

URL

https://www.tandfonline.com/doi/full/10.1080/10610278.2020.1714620

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=241110&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Albina Yulduzovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=241110&p_lang=2	ru_RU
dc.description.abstract	Supramolecular Chemistry	ru_RU
dc.description.abstract	Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.title	Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene	ru_RU
dc.type	Articles in international journals and collections	ru_RU