Form of presentation | Articles in international journals and collections |
Year of publication | 2020 |
Язык | английский |
|
Ziganshina Albina Yulduzovna, author
|
Bibliographic description in the original language |
Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161. |
Annotation |
Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells. |
Keywords |
резорцинарен, наноноситель |
The name of the journal |
Supramolecular Chemistry
|
URL |
https://www.tandfonline.com/doi/full/10.1080/10610278.2020.1714620 |
Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=241110&p_lang=2 |
Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Ziganshina Albina Yulduzovna |
ru_RU |
dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2020 |
ru_RU |
dc.identifier.citation |
Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161. |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=241110&p_lang=2 |
ru_RU |
dc.description.abstract |
Supramolecular Chemistry |
ru_RU |
dc.description.abstract |
Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
резорцинарен |
ru_RU |
dc.subject |
наноноситель |
ru_RU |
dc.title |
Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene |
ru_RU |
dc.type |
Articles in international journals and collections |
ru_RU |
|