KFU. Card publication. Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma.

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RELATIONSHIP OF SERUM LEVELS OF IL-17, IL-18, TNF-α, AND LUNG FUNCTION PARAMETERS IN PATIENTS WITH COPD, ASTHMA-COPD OVERLAP, AND BRONCHIAL ASTHMA.

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Bayrasheva Venera Rustamovna, author

Kubysheva Nailya Iskhakovna, author

Solovev Valeriy Dmitrievich, author

Other authors

Batyrshin Ildar , author

Boldina Marina , author

Eliseeva Tatyana , author

Khaletskaya Anastasia , author

Klimanov Igor , author

Ovsyannikov Dmitry Yu. , author

Ramírez-Salinas Marco Antonio , author

Salinas-Rosales Moisés , author

Soodaeva Svetlana , author

Villa-Vargas Luis Alfonso Villa-Vargas , author

Bibliographic description in the original language

Kubysheva, N., Boldina, M., Eliseeva, T., Soodaeva, S., Klimanov, I., Khaletskaya, A., ... & Salinas-Rosales, M. (2020). Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma. Mediators of Inflammation, 2020.

Annotation

Mediators of Inflammation

Keywords

IL-17, IL-18, TNF, COPD, bronchial asthma, asthma-COPD overlap

The name of the journal

Mediators of Inflammation

URL

http://downloads.hindawi.com/journals/mi/2020/4652898.pdf

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=240874&p_lang=2

Resource files

File name	Size (MB)	Format
Relationship_of_Serum_Levels_IL_17__IL_18__TNF___945__and_Lung_Function_in_COPD__Asthma_COPD_Overlap_and_Asthma.pdf	0,79	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bayrasheva Venera Rustamovna	ru_RU
dc.contributor.author	Kubysheva Nailya Iskhakovna	ru_RU
dc.contributor.author	Solovev Valeriy Dmitrievich	ru_RU
dc.contributor.author	Batyrshin Ildar	ru_RU
dc.contributor.author	Boldina Marina	ru_RU
dc.contributor.author	Eliseeva Tatyana	ru_RU
dc.contributor.author	Khaletskaya Anastasia	ru_RU
dc.contributor.author	Klimanov Igor	ru_RU
dc.contributor.author	Ovsyannikov Dmitry Yu.	ru_RU
dc.contributor.author	Ramírez-Salinas Marco Antonio	ru_RU
dc.contributor.author	Salinas-Rosales Moisés	ru_RU
dc.contributor.author	Soodaeva Svetlana	ru_RU
dc.contributor.author	Villa-Vargas Luis Alfonso Villa-Vargas	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Kubysheva, N., Boldina, M., Eliseeva, T., Soodaeva, S., Klimanov, I., Khaletskaya, A., ... & Salinas-Rosales, M. (2020). Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma. Mediators of Inflammation, 2020.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=240874&p_lang=2	ru_RU
dc.description.abstract	Mediators of Inflammation	ru_RU
dc.description.abstract	Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis andimprovement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchialasthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18, and TNF-αin patients with COPD, ACO, and BA with various severity of the disease, as well as evaluation of the relationship between thelevel of these cytokines and lung ventilation function. A total of 147 patients with COPD (n=58), ACO (n=57), and BA(n=32) during a stable period have been examined in this study. The control group included 21 healthy nonsmokers withsimilar sex-age indicators. Serum levels of IL-17, IL-18, and TNF-αwere determined by ELISA. The concentrations of thesecytokines in the circulation in the studied patients with COPD, ACO, and BA were higher than those in healthy nonsmokers(p≤0:001). IL-17 and IL-18 levels in the blood serum were comparable in all examined patients. The mean TNF-αconcentrations in the circulation in COPD and ACO were significantly higher than those in BA (p<0:001). In patients withCOPD, the levels of IL-17 and TNF-αincreased progressively against the background of a decrease in numerous spirometricindicators, which allows us to consider these cytokines as systemic biomarkers of disease severity. In BA, the inverse correlationsbetween the level of IL-17 and FEV1/FVC (%) and FEV1 have been found. In patients with ACO, the increase in IL-18 levelswas associated with a decrease in FEV1 and TNF-αwith FEV1/FVC (%). Thesefindings indicate that IL-17, IL-18, and TNF-αcan participate in the mechanisms of systemic inflammation and the genesis of disorders of airway obstruction in COPD, A�O,and BA. An increase in the levels of IL-17 and TNF-αmay be associated with impaired bronchial patency in COPD and BA.The established associations of the IL-18 concentration in the blood serum and FEV1 only in patients with ACO allow using thelevel of IL-18 as a potential marker of the degree of impaired airway obstruction in this disease.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	IL-17	ru_RU
dc.subject	IL-18	ru_RU
dc.subject	TNF	ru_RU
dc.subject	COPD	ru_RU
dc.subject	bronchial asthma	ru_RU
dc.subject	asthma-COPD overlap	ru_RU
dc.title	Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma.	ru_RU
dc.type	Articles in international journals and collections	ru_RU